CEBPD

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[5][6]

CEBPD
Identifiers
Aliases	CEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta, CCAAT/enhancer binding protein delta, CCAAT enhancer binding protein delta
External IDs	OMIM: 116898 MGI: 103573 HomoloGene: 3808 GeneCards: CEBPD
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q11.21 Start 47,736,913 bp[1] End 47,738,164 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A2|16 10.09 cM Start 15,887,286 bp[2] End 15,891,031 bp[2]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • protein homodimerization activity • protein heterodimerization activity Cellular component • cell nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • cytokine-mediated signaling pathway • hematopoietic progenitor cell differentiation • regulation of transcription from RNA polymerase II promoter • fat cell differentiation • positive regulation of osteoblast differentiation • negative regulation of transcription, DNA-templated • inner ear development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1052	12609
Ensembl	ENSG00000221869	ENSMUSG00000071637
UniProt	P49716	Q00322
RefSeq (mRNA)	NM_005195	NM_007679
RefSeq (protein)	NP_005186	NP_031705
Location (UCSC)	Chr 8: 47.74 – 47.74 Mb	Chr 16: 15.89 – 15.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[7]

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[8]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[9]

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[10]

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[11]

See also

• Ccaat-enhancer-binding proteins

References

1. GRCh38: Ensembl release 89: ENSG00000221869 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071637 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554.
6. Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
7. "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
8. Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (Feb 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–97. doi:10.1038/sj.onc.1208393. PMID 15674331.
9. Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (Jan 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.
10. Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs (2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy - Nucleic Acids. 5 (9): e366. doi:10.1038/mtna.2016.66. ISSN 2162-2531. PMC 5056990. PMID 27673562.
11. Choy L, Derynck R (Mar 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry. 278 (11): 9609–19. doi:10.1074/jbc.M212259200. PMID 12524424.

Further reading

• Sladek FM, Darnell JE (Apr 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
• Kinoshita S, Akira S, Kishimoto T (Feb 1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1473–6. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402.
• Nagulapalli S, Pongubala JM, Atchison ML (Nov 1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". Journal of Immunology. 155 (9): 4330–8. PMID 7594592.
• Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenetics and Cell Genetics. 70 (3–4): 188–91. doi:10.1159/000134030. PMID 7789168.
• Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J (May 1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics. 16 (2): 520–3. doi:10.1006/geno.1993.1220. PMID 8314590.
• Chen PL, Riley DJ, Chen Y, Lee WH (Nov 1996). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes & Development. 10 (21): 2794–804. doi:10.1101/gad.10.21.2794. PMID 8946919.
• Xia C, Cheshire JK, Patel H, Woo P (Dec 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". The International Journal of Biochemistry & Cell Biology. 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.
• Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (Mar 2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". The Journal of Biological Chemistry. 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938.
• Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E (Dec 2001). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Molecular and Cellular Probes. 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. PMID 11851384. S2CID 8215328.
• Gao H, Parkin S, Johnson PF, Schwartz RC (Oct 2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065.
• Dearth LR, DeWille J (Mar 2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". The Journal of Biological Chemistry. 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732.
• Milde-Langosch K, Löning T, Bamberger AM (May 2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Research and Treatment. 79 (2): 175–85. doi:10.1023/A:1023929504884. PMID 12825852.
• Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR (Sep 2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". The Journal of Biological Chemistry. 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754.
• Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM (Dec 2003). "Molecular responses of human muscle to eccentric exercise". Journal of Applied Physiology. 95 (6): 2485–94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035. S2CID 9817319.
• Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J (Sep 2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiology of Aging. 25 (8): 991–9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823.
• Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW (Nov 2004). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". Journal of Cellular Biochemistry. 93 (4): 844–56. doi:10.1002/jcb.20224. PMID 15389878.

External links

• Human CEBPD genome location and CEBPD gene details page in the UCSC Genome Browser.
• CEBPD+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.