Neurogenin-2

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.[5]

NEUROG2
Identifiers
Aliases	NEUROG2, Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2
External IDs	OMIM: 606624 MGI: 109619 HomoloGene: 7633 GeneCards: NEUROG2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q25 Start 112,513,516 bp[1] End 112,516,180 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G2 Start 127,633,135 bp[2] End 127,635,631 bp[2]
Gene ontology Molecular function • DNA binding • E-box binding • protein dimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • multicellular organism development • nervous system development • regulation of transcription, DNA-templated • positive regulation of sequence-specific DNA binding transcription factor activity • neuron differentiation • cell differentiation • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	63973	11924
Ensembl	ENSG00000178403	ENSMUSG00000027967
UniProt	Q9H2A3	P70447
RefSeq (mRNA)	NM_024019	NM_009718
RefSeq (protein)	NP_076924	NP_033848
Location (UCSC)	Chr 4: 112.51 – 112.52 Mb	Chr 3: 127.63 – 127.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000178403 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027967 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: neurogenin 2".
6. Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F (September 2008). "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature. 455 (7209): 114–8. Bibcode:2008Natur.455..114H. doi:10.1038/nature07198. PMID 18690213.

Further reading

• Gradwohl G, Fode C, Guillemot F (1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Dev. Biol. 180 (1): 227–41. doi:10.1006/dbio.1996.0297. PMID 8948587.
• Simmons AD, Horton S, Abney AL, Johnson JE (2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers". Dev. Biol. 229 (2): 327–39. doi:10.1006/dbio.2000.9984. PMID 11203697.
• Kumar M, Bagchi B, Gupta SK, et al. (2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells". Stem Cells Dev. 16 (4): 667–81. doi:10.1089/scd.2006.0115. PMID 17784840.
• Deng S, Deng H, Le W, et al. (2009). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease". Neurosci. Lett. 468 (3): 195–197. doi:10.1016/j.neulet.2009.10.078. PMID 19879328.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Park CH, Kang JS, Yoon EH, et al. (2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Lett. 582 (5): 537–42. doi:10.1016/j.febslet.2008.01.018. PMID 18242186.
• Fode C, Gradwohl G, Morin X, et al. (1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron. 20 (3): 483–94. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123.