NKX2-3

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.[5][6][7]

NKX2-3
Identifiers
Aliases	NKX2-3, CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3
External IDs	OMIM: 606727 MGI: 97348 HomoloGene: 17061 GeneCards: NKX2-3
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 99,532,942 bp[1] End 99,536,524 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 36.67 cM Start 43,612,325 bp[2] End 43,615,892 bp[2]
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • molecular function • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity Cellular component • cell nucleus • cellular component Biological process • leukocyte homeostasis • CD4-positive, alpha-beta T cell differentiation • post-embryonic digestive tract morphogenesis • regulation of transcription, DNA-templated • plasma cell differentiation • spleen development • post-embryonic development • transcription, DNA-templated • macrophage differentiation • mucosal-associated lymphoid tissue development • odontogenesis of dentin-containing tooth • gland morphogenesis • regulation of cell proliferation • immune response • B cell differentiation • Peyer's patch development • digestive tract development • lymph node development • triglyceride metabolic process • leukocyte migration • positive regulation of transcription from RNA polymerase II promoter • biological process • cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	159296	18089
Ensembl	ENSG00000119919	ENSMUSG00000044220
UniProt	Q8TAU0	P97334
RefSeq (mRNA)	NM_145285	NM_008699
RefSeq (protein)	NP_660328	NP_032725
Location (UCSC)	Chr 10: 99.53 – 99.54 Mb	Chr 19: 43.61 – 43.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000119919 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044220 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742.
6. Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.
7. "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

Further reading

• Harvey RP (1996). "NK-2 homeobox genes and heart development". Dev. Biol. 178 (2): 203–16. doi:10.1006/dbio.1996.0212. PMID 8812123.
• Pabst O, Zweigerdt R, Arnold HH (1999). "Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen". Development. 126 (10): 2215–25. PMID 10207146.
• Phiel CJ, Gabbeta V, Parsons LM, et al. (2001). "Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues". J. Biol. Chem. 276 (37): 34637–50. doi:10.1074/jbc.M105826200. PMID 11457859.
• Biben C, Wang CC, Harvey RP (2003). "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis". Int. J. Dev. Biol. 46 (4): 415–22. PMID 12141427.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.