PHF20

PHD finger protein 20 is a protein that in humans is encoded by the PHF20 gene.[5]

PHF20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P8D, 3Q1J, 3QII, 3SD4
Identifiers
Aliases	PHF20, C20orf104, GLEA2, HCA58, NZF, TDRD20A, TZP, PHD finger protein 20
External IDs	OMIM: 610335 MGI: 2444148 HomoloGene: 9507 GeneCards: PHF20
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22-q11.23 Start 35,771,974 bp[1] End 35,950,370 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,196,466 bp[2] End 156,309,952 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • histone acetyltransferase activity (H4-K8 specific) • DNA binding • histone acetyltransferase activity (H4-K5 specific) • metal ion binding • histone acetyltransferase activity (H4-K16 specific) • GO:0001948 protein binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nuclear membrane • histone acetyltransferase complex • cell nucleus • nucleoplasm • cytosol • MLL1 complex Biological process • histone H4-K16 acetylation • regulation of transcription, DNA-templated • transcription, DNA-templated • histone H4-K5 acetylation • histone H4-K8 acetylation • regulation of signal transduction by p53 class mediator • chromatin organization • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51230	228829
Ensembl	ENSG00000025293	ENSMUSG00000038116
UniProt	Q9BVI0 Q5JWZ0	Q8BLG0
RefSeq (mRNA)	NM_016436	NM_172674
RefSeq (protein)	NP_057520	NP_766262
Location (UCSC)	Chr 20: 35.77 – 35.95 Mb	Chr 2: 156.2 – 156.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000025293 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038116 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PHF20 PHD finger protein 20".

Further reading

• Fischer U, Struss AK, Hemmer D, Pallasch CP, Steudel WI, Meese E (November 2001). "Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls". Clin. Exp. Immunol. 126 (2): 206–13. doi:10.1046/j.1365-2249.2001.01635.x. PMC 1906187. PMID 11703362.
• Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, Eigenstetter G, Zobywalski C, Müller-Weihrich S, Graubner U, Schmid I, Sackerer D, Späth M, Goetz C, Prantl F, Asmuss HP, Bise K, Mautner J (August 2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201.
• Pallasch CP, Struss AK, Munnia A, König J, Steudel WI, Fischer U, Meese E (November 2005). "Autoantibodies against GLEA2 and PHF3 in glioblastoma: tumor-associated autoantibodies correlated with prolonged survival". Int. J. Cancer. 117 (3): 456–9. doi:10.1002/ijc.20929. PMID 15906353.
• Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G (August 2012). "PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53". Nat. Struct. Mol. Biol. 19 (9): 916–24. doi:10.1038/nsmb.2353. PMC 3454513. PMID 22864287.

External links

• PHF20+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.