Y box binding protein 1

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.[5]

YBX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H95
Identifiers
Aliases	YBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, CBF-A, EFI-A, Y-box binding protein 1
External IDs	OMIM: 154030 MGI: 99146 HomoloGene: 88707 GeneCards: YBX1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 42,682,418 bp[1] End 42,703,805 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.1 Start 119,277,981 bp[2] End 119,294,604 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948 protein binding • RNA binding • nucleic acid binding • GTPase binding • double-stranded DNA binding • single-stranded DNA binding • chromatin binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • CRD-mediated mRNA stability complex • nuclear membrane • intracellular membrane-bounded organelle • U12-type spliceosomal complex • nucleoplasm • extracellular region • cytoplasmic stress granule • extracellular exosome • cell nucleus • histone pre-mRNA 3'end processing complex • cytosol • ribonucleoprotein Biological process • CRD-mediated mRNA stabilization • mRNA splicing, via spliceosome • regulation of transcription, DNA-templated • mRNA processing • transcription from RNA polymerase II promoter • protein localization to cytoplasmic stress granule • transcription, DNA-templated • positive regulation of cell division • positive regulation of transcription from RNA polymerase II promoter • in utero embryonic development • RNA splicing • negative regulation of striated muscle cell differentiation • negative regulation of transcription from RNA polymerase II promoter • Notch signaling pathway • cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4904	22608
Ensembl	ENSG00000065978	ENSMUSG00000028639
UniProt	P67809	P62960
RefSeq (mRNA)	NM_004559	NM_011732
RefSeq (protein)	NP_004550	NP_035862
Location (UCSC)	Chr 1: 42.68 – 42.7 Mb	Chr 4: 119.28 – 119.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

YBX1 is a potential drug target in cancer therapy.[6] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.[6] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

Interactions

Y box binding protein 1 has been shown to interact with:

• ANKRD2,[7]
• CTCF,[8]
• P53,[7][9]
• PCNA,[10]
• RBBP6,[11] and
• SFRS9.[12]

References

1. GRCh38: Ensembl release 89: ENSG00000065978 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028639 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: YBX1 Y box binding protein 1".
6. Lage H, Surowiak P, Holm PS (November 2008). "[YB-1 as a potential target in cancer therapy]". Pathologe (in German). 29 Suppl 2: 187–90. doi:10.1007/s00292-008-1030-2. PMID 18773210.
7. Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. PMID 15136035.
8. Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, Lobanenkov VV, Klenova EM (2000). "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". J. Biol. Chem. 275 (38): 29915–21. doi:10.1074/jbc.M001538200. PMID 10906122.
9. Okamoto T, Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K (2000). "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene. 19 (54): 6194–202. doi:10.1038/sj.onc.1204029. PMID 11175333.
10. Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID 9927044.
11. Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979.
12. Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, Mertens PR (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. PMID 12604611.

Further reading

• Kolluri R, Torrey TA, Kinniburgh AJ (1992). "A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif". Nucleic Acids Res. 20 (1): 111–6. doi:10.1093/nar/20.1.111. PMC 5356827. PMID 1738588.
• Kolluri R, Kinniburgh AJ (1991). "Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein". Nucleic Acids Res. 19 (17): 4771. doi:10.1093/nar/19.17.4771. PMC 328725. PMID 1891370.
• Sakura H, Maekawa T, Imamoto F, et al. (1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene. 73 (2): 499–507. doi:10.1016/0378-1119(88)90514-8. PMID 2977358.
• Didier DK, Schiffenbauer J, Woulfe SL, et al. (1988). "Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7322–6. doi:10.1073/pnas.85.19.7322. PMC 282178. PMID 3174636.
• Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain". Eur. J. Biochem. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID 7628487.
• Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins". Mol. Cell. Biol. 15 (9): 5092–9. PMC 230756. PMID 7651426.
• Chen NN, Chang CF, Gallia GL, et al. (1995). "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1087–91. doi:10.1073/pnas.92.4.1087. PMC 42642. PMID 7862639.
• Horwitz EM, Maloney KA, Ley TJ (1994). "A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes". J. Biol. Chem. 269 (19): 14130–9. PMID 8188694.
• Kashanchi F, Duvall JF, Dittmer J, et al. (1994). "Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression". J. Virol. 68 (1): 561–5. PMC 236322. PMID 8254772.
• Makino Y, Ohga T, Toh S, et al. (1996). "Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter". Nucleic Acids Res. 24 (10): 1873–8. doi:10.1093/nar/24.10.1873. PMC 145870. PMID 8657568.
• Funke B, Zuleger B, Benavente R, et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins". Nucleic Acids Res. 24 (19): 3821–8. doi:10.1093/nar/24.19.3821. PMC 146158. PMID 8871564.
• Koike K, Uchiumi T, Ohga T, et al. (1998). "Nuclear translocation of the Y-box binding protein by ultraviolet irradiation". FEBS Lett. 417 (3): 390–4. doi:10.1016/S0014-5793(97)01296-9. PMID 9409758.
• Toh S, Nakamura T, Ohga T, et al. (1998). "Genomic organization of the human Y-box protein (YB-1) gene". Gene. 206 (1): 93–7. doi:10.1016/S0378-1119(97)00570-2. PMID 9461420.
• Sawaya BE, Khalili K, Amini S (1998). "Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat". J. Gen. Virol. 79. ( Pt 2): 239–46. doi:10.1099/0022-1317-79-2-239. PMID 9472608.
• Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH (1999). "A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription". J. Biol. Chem. 273 (49): 32957–65. doi:10.1074/jbc.273.49.32957. PMID 9830047.
• Ise T, Nagatani G, Imamura T, et al. (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID 9927044.
• Safak M, Gallia GL, Khalili K (1999). "Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells". Mol. Cell. Biol. 19 (4): 2712–23. doi:10.1128/mcb.19.4.2712. PMC 84064. PMID 10082537.
• Kelm RJ, Cogan JG, Elder PK, et al. (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". J. Biol. Chem. 274 (20): 14238–45. doi:10.1074/jbc.274.20.14238. PMID 10318844.
• Safak M, Gallia GL, Ansari SA, Khalili K (1999). "Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen". J. Virol. 73 (12): 10146–57. PMC 113067. PMID 10559330.
• Ansari SA, Safak M, Gallia GL, et al. (1999). "Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity". J. Gen. Virol. 80. ( Pt 10): 2629–38. doi:10.1099/0022-1317-80-10-2629. PMID 10573156.
• Basaki Y, Hosoi F, Oda Y, et al. (2007). "Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells". Oncogene. 26 (19): 2736–46. doi:10.1038/sj.onc.1210084. PMID 17072343.

External links

• YBX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.