HOXB2

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.[5][6][7]

HOXB2
Identifiers
Aliases	HOXB2, HOX2, HOX2H, Hox-2.8, K8, homeobox B2
External IDs	OMIM: 142967 MGI: 96183 HomoloGene: 37584 GeneCards: HOXB2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,540,894 bp[1] End 48,544,989 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.85 cM Start 96,350,525 bp[2] End 96,354,012 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component • cell nucleus • nucleoplasm • cytosol • nuclear speck Biological process • multicellular organism development • regulation of transcription, DNA-templated • blood circulation • transcription, DNA-templated • morphogenesis of an epithelial sheet • anterior/posterior pattern specification • dorsal/ventral pattern formation • rhombomere 3 development • rhombomere 4 development • facial nerve structural organization • embryonic skeletal system morphogenesis • skeletal system morphogenesis • neural nucleus development • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3212	103889
Ensembl	ENSG00000173917	ENSMUSG00000075588
UniProt	P14652	P0C1T1
RefSeq (mRNA)	NM_002145	NM_134032
RefSeq (protein)	NP_002136	NP_598793
Location (UCSC)	Chr 17: 48.54 – 48.54 Mb	Chr 11: 96.35 – 96.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[7]

See also

• Homeobox

References

1. GRCh38: Ensembl release 89: ENSG00000173917 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075588 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
6. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
7. "Entrez Gene: HOXB2 homeobox B2".

Further reading

• Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J (Aug 1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences". Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 7318–22. doi:10.1073/pnas.88.16.7318. PMC 52286. PMID 1871139.
• Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Kongsuwan K, Webb E, Housiaux P, Adams JM (Jul 1988). "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages". The EMBO Journal. 7 (7): 2131–8. doi:10.1002/j.1460-2075.1988.tb03052.x. PMC 454515. PMID 2901346.
• Vieille-Grosjean I, Huber P (Mar 1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells". The Journal of Biological Chemistry. 270 (9): 4544–50. doi:10.1074/jbc.270.9.4544. PMID 7876223.
• Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal. 13 (14): 3339–47. doi:10.1002/j.1460-2075.1994.tb06636.x. PMC 395231. PMID 7913891.
• Guazzi S, Pintonello ML, Viganò A, Boncinelli E (May 1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". The Journal of Biological Chemistry. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.
• Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM (Apr 1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain". Neuron. 22 (4): 677–91. doi:10.1016/S0896-6273(00)80728-X. PMID 10230789.
• Case SS, Huber P, Lloyd JA (Nov 1999). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation". DNA and Cell Biology. 18 (11): 805–17. doi:10.1089/104454999314809. PMID 10595394.
• Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF (Mar 2001). "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema". The American Journal of Pathology. 158 (3): 955–66. doi:10.1016/S0002-9440(10)64042-4. PMC 1850338. PMID 11238043.
• Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
• Liu X, Zhang X (Feb 2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells". Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi / Chinese Medical Association. 5 (1): 12–5. PMID 11835749.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A (Jun 2003). "Regulation of Hoxb2 by APL-associated PLZF protein". Oncogene. 22 (24): 3685–97. doi:10.1038/sj.onc.1206328. PMID 12802276.
• Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM (May 2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia". Clinical Cancer Research. 11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264.

External links

• HOXB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.