HES5

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.[5][6]

HES5
Identifiers
Aliases	HES5, bHLHb38, hes family bHLH transcription factor 5
External IDs	OMIM: 607348 MGI: 104876 HomoloGene: 7755 GeneCards: HES5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.32 Start 2,528,745 bp[1] End 2,530,263 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 86.01 cM Start 154,960,923 bp[2] End 154,962,371 bp[2]
Gene ontology Molecular function • DNA binding • protein dimerization activity • transcription factor binding • chromatin binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • double-stranded DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • sequence-specific DNA binding • sequence-specific double-stranded DNA binding Cellular component • nucleoplasm • cell nucleus • cellular component Biological process • Notch signaling pathway • auditory receptor cell fate determination • establishment of epithelial cell polarity • cell differentiation • negative regulation of astrocyte differentiation • regulation of auditory receptor cell differentiation • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • inner ear receptor stereocilium organization • comma-shaped body morphogenesis • metanephric nephron tubule morphogenesis • chondrocyte differentiation • central nervous system myelination • negative regulation of transcription from RNA polymerase II promoter • cell maturation • negative regulation of forebrain neuron differentiation • transcription, DNA-templated • nervous system development • negative regulation of stem cell differentiation • neuronal stem cell population maintenance • positive regulation of transcription, DNA-templated • multicellular organism development • glial cell fate commitment • telencephalon development • brain development • auditory receptor cell differentiation • cell adhesion • astrocyte differentiation • cartilage development • forebrain radial glial cell differentiation • regulation of myelination • negative regulation of oligodendrocyte differentiation • S-shaped body morphogenesis • neural tube development • neuron differentiation • positive regulation of cell proliferation • positive regulation of BMP signaling pathway • negative regulation of pro-B cell differentiation • regulation of cell differentiation • smoothened signaling pathway • oligodendrocyte development • camera-type eye development • specification of loop of Henle identity • regulation of epithelial cell proliferation • negative regulation of transcription, DNA-templated • negative regulation of inner ear receptor cell differentiation • regulation of neurogenesis • positive regulation of JAK-STAT cascade • positive regulation of Notch signaling pathway • positive regulation of transcription from RNA polymerase II promoter • positive regulation of smooth muscle cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein • macromolecular complex assembly • somitogenesis • central nervous system development • anterior/posterior pattern specification • negative regulation of auditory receptor cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	388585	15208
Ensembl	ENSG00000273529 ENSG00000197921	ENSMUSG00000048001
UniProt	Q5TA89	P70120
RefSeq (mRNA)	NM_001010926	NM_010419 NM_001370755
RefSeq (protein)	NP_001010926	NP_034549 NP_001357684
Location (UCSC)	Chr 1: 2.53 – 2.53 Mb	Chr 4: 154.96 – 154.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

HES5 regulates brain development process.[7] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.[8] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.[9]

References

1. ENSG00000197921 GRCh38: Ensembl release 89: ENSG00000273529, ENSG00000197921 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048001 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (Feb 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". J Biol Chem. 270 (3): 1342–9. doi:10.1074/jbc.270.3.1342. PMID 7836401.
6. "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)".
7. Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development. 131 (22): 5539–50. doi:10.1242/dev.01436. PMID 15496443.
8. Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". Int. J. Gynecol. Cancer. 17 (6): 1293–9. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915.
9. Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gazit R, Krizhanovsky V, Ben-Arie N (2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway". Development. 131 (4): 903–13. doi:10.1242/dev.00982. PMID 14757642.
• Nakatani T, Mizuhara E, Minaki Y, et al. (2004). "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system". J. Biol. Chem. 279 (16): 16356–67. doi:10.1074/jbc.M311740200. PMID 14764602.
• Kamakura S, Oishi K, Yoshimatsu T, et al. (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nat. Cell Biol. 6 (6): 547–54. doi:10.1038/ncb1138. PMID 15156153.
• Katoh M, Katoh M (2005). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". Int. J. Oncol. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Ohtsuka T, Imayoshi I, Shimojo H, et al. (2006). "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice". Mol. Cell. Neurosci. 31 (1): 109–22. doi:10.1016/j.mcn.2005.09.006. PMID 16214363.
• Ong CT, Cheng HT, Chang LW, et al. (2006). "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability". J. Biol. Chem. 281 (8): 5106–19. doi:10.1074/jbc.M506108200. PMID 16365048.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Karlsson C, Brantsing C, Svensson T, et al. (2007). "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors". J. Orthop. Res. 25 (2): 152–63. doi:10.1002/jor.20287. PMID 17072841.
• Karlsson C, Jonsson M, Asp J, et al. (2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926.

External links

• HES5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.