TAL2

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.[5][6]

TAL2
Identifiers
Aliases	TAL2, TAL bHLH transcription factor 2
External IDs	OMIM: 186855 MGI: 99540 HomoloGene: 3954 GeneCards: TAL2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.2 Start 105,662,457 bp[1] End 105,663,124 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B2|4 28.75 cM Start 53,779,705 bp[2] End 53,788,712 bp[2]
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001948 protein binding • protein dimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • regulation of transcription, DNA-templated • post-embryonic development • transcription, DNA-templated • midbrain development • multicellular organism growth • thalamus development • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6887	21350
Ensembl	ENSG00000186051	ENSMUSG00000028417
UniProt	Q16559	Q62282
RefSeq (mRNA)	NM_005421	NM_009317
RefSeq (protein)	NP_005412	NP_033343
Location (UCSC)	Chr 9: 105.66 – 105.66 Mb	Chr 4: 53.78 – 53.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

TAL2 is a member of the basic helix-loop-helix family of transcription factors.[7]

Clinical significance

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).[6][8]

References

1. GRCh38: Ensembl release 89: ENSG00000186051 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028417 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2".
6. Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
7. Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619.
8. Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Marculescu R, Vanura K, Le T, et al. (2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Xia Y, Hwang LY, Cobb MH, Baer R (1994). "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity". Oncogene. 9 (5): 1437–46. PMID 8152805.
• Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
• Xia Y, Brown L, Yang CY, et al. (1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
• Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein". Blood. 80 (11): 2858–66. doi:10.1182/blood.V80.11.2858.bloodjournal80112858. PMID 1450410.