TAL1

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.[5][6]

TAL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YPA, 2YPB
Identifiers
Aliases	TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor
External IDs	OMIM: 187040 MGI: 98480 HomoloGene: 2400 GeneCards: TAL1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p33 Start 47,216,290 bp[1] End 47,232,220 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D1|4 52.73 cM Start 115,056,426 bp[2] End 115,071,755 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein dimerization activity • RNA polymerase II transcription factor binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • histone deacetylase binding • chromatin binding • transcription regulatory region sequence-specific DNA binding • E-box binding • GO:0001948 protein binding • protein heterodimerization activity • enzyme binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • histone deacetylase complex • transcription factor complex • nuclear chromatin • Lsd1/2 complex • cell nucleus • nucleoplasm • macromolecular complex Biological process • megakaryocyte development • megakaryocyte differentiation • myeloid cell differentiation • cell fate commitment • cell differentiation • regulation of transcription, DNA-templated • regulation of mast cell differentiation • spinal cord association neuron differentiation • positive regulation of protein complex assembly • locomotory behavior • positive regulation of erythrocyte differentiation • regulation of transcription from RNA polymerase II promoter • regulation of stem cell population maintenance • platelet formation • positive regulation of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • generation of neurons • basophil differentiation • positive regulation of transcription, DNA-templated • multicellular organism development • regulation of cell proliferation • hematopoietic stem cell differentiation • astrocyte fate commitment • angiogenesis • neuron differentiation • embryonic hemopoiesis • positive regulation of chromatin assembly or disassembly • erythrocyte differentiation • definitive hemopoiesis • regulation of myeloid cell differentiation • positive regulation of cell division • hemangioblast cell differentiation • positive regulation of transcription from RNA polymerase II promoter • erythrocyte maturation • regulation of hematopoietic stem cell differentiation • haematopoiesis • transcription from RNA polymerase II promoter • negative regulation of erythrocyte differentiation • positive regulation of protein tyrosine kinase activity • positive regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6886	21349
Ensembl	ENSG00000162367	ENSMUSG00000028717
UniProt	P17542	P22091
RefSeq (mRNA)	NM_001287347 NM_001290403 NM_001290404 NM_001290405 NM_001290406 NM_003189	NM_011527 NM_001287388
RefSeq (protein)	NP_001274276 NP_001277332 NP_001277333 NP_001277334 NP_001277335 NP_003180	NP_001274317 NP_035657
Location (UCSC)	Chr 1: 47.22 – 47.23 Mb	Chr 4: 115.06 – 115.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions

TAL1 has been shown to interact with:

• CBFA2T3,[7]
• EP300,[8]
• GATA1,[7][9]
• LDB1,[7]
• LMO1,[10][11]
• LMO2,[7][9][10][11]
• SIN3A,[12]
• Sp1 transcription factor,[13] and
• TCF3.[7][14]

References

1. GRCh38: Ensembl release 89: ENSG00000162367 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028717 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A. 86 (13): 5039–43. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.
6. "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".
7. Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.
8. Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.
9. Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
10. Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
11. Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
12. Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.
13. Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood. 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.
14. Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.

Further reading

• Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors". Int. J. Cell Cloning. 10 (5): 269–76. doi:10.1002/stem.5530100504. PMID 1453013.
• Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD, Kirsch IR (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia". Blood. 79 (5): 1327–33. PMID 1311214.
• Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation". EMBO J. 11 (11): 4073–81. PMC 556917. PMID 1396592.
• Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein". Blood. 80 (11): 2858–66. doi:10.1182/blood.V80.11.2858.bloodjournal80112858. PMID 1450410.
• Bernard O, Lecointe N, Jonveaux P, Souyri M, Mauchauffé M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene". Oncogene. 6 (8): 1477–88. PMID 1886719.
• Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ, Mathieu-Mahul D (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias". Genes Chromosomes Cancer. 1 (3): 194–208. doi:10.1002/gcc.2870010303. PMID 1964581.
• Chen Q, Yang CY, Tsan JT, Xia Y, Ragab AH, Peiper SC, Carroll A, Baer R (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia". J. Exp. Med. 172 (5): 1403–8. doi:10.1084/jem.172.5.1403. PMC 2188666. PMID 2230650.
• Aplan PD, Begley CG, Bertness V, Nussmeier M, Ezquerra A, Coligan J, Kirsch IR (1991). "The SCL gene is formed from a transcriptionally complex locus". Mol. Cell. Biol. 10 (12): 6426–35. PMC 362919. PMID 2247063.
• Chen Q, Cheng JT, Tasi LH, Schneider N, Buchanan G, Carroll A, Crist W, Ozanne B, Siciliano MJ, Baer R (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein". EMBO J. 9 (2): 415–24. doi:10.1002/j.1460-2075.1990.tb08126.x. PMC 551682. PMID 2303035.
• Begley CG, Aplan PD, Denning SM, Haynes BF, Waldmann TA, Kirsch IR (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. doi:10.1073/pnas.86.24.10128. PMC 298658. PMID 2602361.
• Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
• Pulford K, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY (1995). "Expression of TAL-1 proteins in human tissues". Blood. 85 (3): 675–84. PMID 7833471.
• Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
• Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
• Cross MA, Heyworth CM, Murrell AM, Bockamp EO, Dexter TM, Green AR (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line". Oncogene. 9 (10): 3013–6. PMID 8084606.
• Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.
• Hwang LY, Siegelman M, Davis L, Oppenheimer-Marks N, Baer R (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen". Oncogene. 8 (11): 3043–6. PMID 8414504.
• Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1". Mol. Cell. Biol. 13 (2): 801–8. PMC 358963. PMID 8423803.

External links

• TAL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook TAL1