ZNF346

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.[5][6]

ZNF346
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MKD, 2MKN
Identifiers
Aliases	ZNF346, JAZ, Zfp346, zinc finger protein 346
External IDs	OMIM: 605308 MGI: 1349417 HomoloGene: 8073 GeneCards: ZNF346
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 177,022,696 bp[1] End 177,081,189 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,105,311 bp[2] End 55,134,825 bp[2]
Gene ontology Molecular function • enzyme binding • double-stranded RNA binding • zinc ion binding • p53 binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • RNA binding • miRNA binding Cellular component • cytoplasm • nucleolus • cell nucleus Biological process • intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23567	26919
Ensembl	ENSG00000113761	ENSMUSG00000021481
UniProt	Q9UL40	Q9R0B7
RefSeq (mRNA)	NM_001308213 NM_001308214 NM_001308215 NM_001308216 NM_001308218 NM_001308219 NM_001308221 NM_001308223 NM_012279 NM_001363713	NM_012017
RefSeq (protein)	NP_001295142 NP_001295143 NP_001295144 NP_001295145 NP_001295147 NP_001295148 NP_001295150 NP_001295152 NP_036411 NP_001350642	NP_036147 NP_001365863 NP_001365864
Location (UCSC)	Chr 5: 177.02 – 177.08 Mb	Chr 13: 55.11 – 55.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000113761 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021481 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang M, May WS, Ito T (Nov 1999). "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization". J Biol Chem. 274 (39): 27399–406. doi:10.1074/jbc.274.39.27399. PMID 10488071.
6. "Entrez Gene: ZNF346 zinc finger protein 346".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Chen T, Brownawell AM, Macara IG (2004). "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5". Mol. Cell. Biol. 24 (15): 6608–19. doi:10.1128/MCB.24.15.6608-6619.2004. PMC 444848. PMID 15254228.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• ZNF346+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.