ZNF644

Zing finger protein 644 (ZNF644) also known as zinc finger motif enhancer-binding protein 2 (Zep-2) is a protein that in humans is encoded by the ZNF644 gene.[5]

ZNF644
Identifiers
Aliases	ZNF644, BM-005, MYP21, NatF, ZEP-2, zinc finger protein 644
External IDs	OMIM: 614159 MGI: 1277212 HomoloGene: 12971 GeneCards: ZNF644
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.2 Start 90,915,298 bp[1] End 91,022,272 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E5|5 51.43 cM Start 106,616,739 bp[2] End 106,697,287 bp[2]
Gene ontology Molecular function • DNA binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity Cellular component • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84146	52397
Ensembl	ENSG00000122482	ENSMUSG00000049606
UniProt	Q9H582	n/a
RefSeq (mRNA)	NM_016620 NM_032186 NM_201269	NM_026856 NM_001363318 NM_001363319 NM_001363320 NM_001363321 NM_001363322 NM_001363323
RefSeq (protein)	NP_057704 NP_115562 NP_958357	n/a
Location (UCSC)	Chr 1: 90.92 – 91.02 Mb	Chr 5: 106.62 – 106.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical relevance

Mutations in the ZNF644 gene have been found in sporadic cases of high myopia.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000122482 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049606 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: zinc finger protein 644".
6. Shi, Yi (2011). "Exome Sequencing Identifies ZNF644 Mutations in High Myopia". PLoS Genetics. 7 (6): e1002084. doi:10.1371/journal.pgen.1002084. PMC 3111487. PMID 21695231.

Further reading

• Zabaneh D, Balding DJ (2010). "A genome-wide association study of the metabolic syndrome in Indian Asian men". PLoS ONE. 5 (8): e11961. doi:10.1371/journal.pone.0011961. PMC 2915922. PMID 20694148.
• Mulligan P, Westbrook TF, Ottinger M, et al. (2008). "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation". Mol. Cell. 32 (5): 718–26. doi:10.1016/j.molcel.2008.10.025. PMC 6595072. PMID 19061646.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.