NKX6-1

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.[5][6]

NKX6-1
Identifiers
Aliases	NKX6-1, NKX6.1, NKX6A, NK6 homeobox 1
External IDs	OMIM: 602563 MGI: 1206039 HomoloGene: 4495 GeneCards: NKX6-1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.23 Start 84,491,987 bp[1] End 84,498,450 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E4 Start 101,658,139 bp[2] End 101,664,996 bp[2]
Gene ontology Molecular function • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • chromatin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • extracellular exosome Biological process • smoothened signaling pathway • detection of glucose • pancreas development • transcription, DNA-templated • regulation of axon extension • multicellular organism development • cellular response to peptide hormone stimulus • central nervous system neuron differentiation • response to nicotine • negative regulation of glial cell differentiation • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification • type B pancreatic cell proliferation • cellular response to cytokine stimulus • positive regulation of sequence-specific DNA binding transcription factor activity • neurogenesis • regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification • type B pancreatic cell development • positive regulation of neuron differentiation • negative regulation of transcription from RNA polymerase II promoter • positive regulation of type B pancreatic cell development • type B pancreatic cell maturation • oligodendrocyte differentiation • regulation of transcription, DNA-templated • cellular proliferation • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • response to drug • positive regulation of glial cell differentiation • cell differentiation • positive regulation of insulin secretion • animal organ morphogenesis • regulation of neuron migration • neuron migration • regulation of insulin secretion • endocrine pancreas development • type B pancreatic cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4825	18096
Ensembl	ENSG00000163623	ENSMUSG00000035187
UniProt	P78426	Q99MA9
RefSeq (mRNA)	NM_006168	NM_144955
RefSeq (protein)	NP_006159	NP_659204
Location (UCSC)	Chr 4: 84.49 – 84.5 Mb	Chr 5: 101.66 – 101.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000163623 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035187 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408.
6. "Entrez Gene: NK6 homeobox 1".

Further reading

• Schisler JC, Fueger PT, Babu DA, et al. (2008). "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1". Mol. Cell. Biol. 28 (10): 3465–76. doi:10.1128/MCB.01791-07. PMC 2423154. PMID 18347054.
• Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736.
• Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999). "Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1". FEBS Lett. 461 (3): 287–94. doi:10.1016/S0014-5793(99)01436-2. PMID 10567713.
• Iype T, Taylor DG, Ziesmann SM, et al. (2004). "The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1". Mol. Endocrinol. 18 (6): 1363–75. doi:10.1210/me.2004-0006. PMID 15056733.
• Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects". Diabetes. 55 (8): 2379–86. doi:10.2337/db05-1203. PMID 16873704.
• Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia". Dig. Dis. Sci. 54 (5): 996–1002. doi:10.1007/s10620-008-0459-8. PMID 18754095.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.