IRX5

Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.[3][4]

IRX5
Identifiers
Aliases	IRX5, HMMS, IRX-2a, IRXB2, iroquois homeobox 5
External IDs	OMIM: 606195 GeneCards: IRX5
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q12.2 Start 54,930,865 bp[1] End 54,934,485 bp[1]
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • vitamin D binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • retinal bipolar neuron differentiation • regulation of gene expression • embryonic cranial skeleton morphogenesis • regulation of transcription, DNA-templated • gonad development • cell development • transcription, DNA-templated • regulation of heart rate • visual perception • neuron maturation • response to stimulus • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10265	n/a
Ensembl	ENSG00000176842	n/a
UniProt	P78411	n/a
RefSeq (mRNA)	NM_001252197 NM_005853	n/a
RefSeq (protein)	NP_001239126 NP_005844	n/a
Location (UCSC)	Chr 16: 54.93 – 54.93 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[3]

References

1. GRCh38: Ensembl release 89: ENSG00000176842 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: iroquois homeobox 1".
4. Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3–4): 320–5. doi:10.1159/000056921. PMID 11435706.

Further reading

• Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
• Bruneau BG (2006). "[Irx5: a transcription factor that regulates the cardiac repolarization gradient]" (PDF). Med Sci (Paris). 22 (3): 231–2. doi:10.1051/medsci/2006223231. PMID 16527195.
• Myrthue A, Rademacher BL, Pittsenbarger J, et al. (2008). "The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells". Clin. Cancer Res. 14 (11): 3562–70. doi:10.1158/1078-0432.CCR-07-4649. PMID 18519790.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kanno S, Kuzuoka H, Sasao S, et al. (2007). "A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses". EMBO J. 26 (8): 2094–103. doi:10.1038/sj.emboj.7601663. PMC 1852789. PMID 17396150.

External links

• IRX5 human gene location in the UCSC Genome Browser.
• IRX5 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.