HOXC10

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.[5][6]

HOXC10
Identifiers
AliasesHOXC10, HOX3I, homeobox C10
External IDsOMIM: 605560 MGI: 96192 HomoloGene: 9680 GeneCards: HOXC10
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.13Start53,985,065 bp[1]
End53,990,279 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3226

209448

Ensembl

ENSG00000180818

ENSMUSG00000022484

UniProt

Q9NYD6

P31257

RefSeq (mRNA)

NM_017409

NM_010462

RefSeq (protein)

NP_059105

NP_034592

Location (UCSC)Chr 12: 53.99 – 53.99 MbChr 15: 102.97 – 102.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.[6]

Pathology

  • HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4.[7]
  • Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to aromatase inhibitors. This epigenetic reprogramming of HOXC10 is observed in endocrine-resistant breast cancer.[8]
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gollark: I really think you're overestimating how much people actually care. There have been various experiments regarding obedience and conformity which suggest that people will basically just do whatever people around them do.
gollark: Consider dying, for instance. People dying is quite bad for a variety of reasons, but because people can't really avoid it it got cognitive-dissonanced into being "good" in a ton of philosophies.
gollark: What?
gollark: I mean, I think people can get used to a lot of things with sufficient time.

References

  1. GRCh38: Ensembl release 89: ENSG00000180818 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022484 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  6. "Entrez Gene: HOXC10 homeobox C10".
  7. Ansari KI, Hussain I, Kasiri S, Mandal SS (Feb 2012). "HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4". Journal of Molecular Endocrinology. 48 (1): 61–75. doi:10.1530/JME-11-0078. PMID 22143955.
  8. Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JP, Richer JK, Elias A, McIlroy M, Young LS, Davidson NE, Schiff R, Li W, Oesterreich S (Mar 2014). "Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer". Science Translational Medicine. 6 (229): 229ra41. doi:10.1126/scitranslmed.3008326. PMC 4277862. PMID 24670685.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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