ZNF146

Zinc finger protein OZF is a protein that in humans is encoded by the ZNF146 gene.[5][6][7]

ZNF146
Identifiers
Aliases	ZNF146, OZF, zinc finger protein 146
External IDs	OMIM: 601505 MGI: 1347092 HomoloGene: 117615 GeneCards: ZNF146
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 36,214,602 bp[1] End 36,238,774 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 30,161,269 bp[2] End 30,169,750 bp[2]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • zinc ion binding • heparin binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nucleolus • cell nucleus • cytosol Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7705	26465
Ensembl	ENSG00000167635	ENSMUSG00000037029
UniProt	Q15072	Q8BQN6
RefSeq (mRNA)	NM_001099638 NM_001099639 NM_007145	NM_011980 NM_001357557
RefSeq (protein)	NP_001093108 NP_001093109 NP_009076	NP_036110 NP_001344486
Location (UCSC)	Chr 19: 36.21 – 36.24 Mb	Chr 7: 30.16 – 30.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Zinc finger

References

1. GRCh38: Ensembl release 89: ENSG00000167635 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037029 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Blottiere L, Apiou F, Ferbus D, Guenzi C, Dutrillaux B, Prosperi MT, Goubin G (Oct 1999). "Cloning, characterization, and chromosome assignment of Zfp146 the mouse ortholog of human ZNF146, a gene amplified and overexpressed in pancreatic cancer, and Zfp260 a closely related gene". Cytogenet Cell Genet. 85 (3–4): 297–300. doi:10.1159/000015316. PMID 10449921.
6. Hayes H, Le Chalony C, Goubin G, Mercier D, Payen E, Bignon C, Kohno K (Jul 1996). "Localization of ZNF164, ZNF146, GGTA1, SOX2, PRLR and EEF2 on homoeologous cattle, sheep and goat chromosomes by fluorescent in situ hybridization and comparison with the human gene map". Cytogenet Cell Genet. 72 (4): 342–6. doi:10.1159/000134218. PMID 8641144.
7. "Entrez Gene: ZNF146 zinc finger protein 146".

Further reading

• Le Chalony C, Prospéri MT, Haluza R, et al. (1994). "The OZF gene encodes a protein consisting essentially of zinc finger motifs". J. Mol. Biol. 236 (2): 399–404. doi:10.1006/jmbi.1994.1151. PMID 8107129.
• Ferbus D, Le Chalony C, Prospéri MT, et al. (1996). "Identification, nuclear localization, and binding activities of OZF, a human protein solely composed of zinc-finger motifs". Eur. J. Biochem. 236 (3): 991–5. doi:10.1111/j.1432-1033.1996.00991.x. PMID 8665923.
• Ferbus D, Fléchon A, Muleris M, et al. (1999). "Amplification and over-expression of OZF, a gene encoding a zinc finger protein, in human pancreatic carcinomas". Int. J. Cancer. 80 (3): 369–72. doi:10.1002/(SICI)1097-0215(19990129)80:3<369::AID-IJC6>3.0.CO;2-Y. PMID 9935176.
• Pibouin L, Villaudy J, Prospéri MT, Goubin G (2001). "Genomic organization and promoter identification of ZNF146, a gene encoding a protein consisting solely of zinc finger domains". Cytogenet. Cell Genet. 92 (1–2): 80–4. doi:10.1159/000056873. PMID 11306801.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ferbus D, Bovin C, Validire P, Goubin G (2003). "The zinc finger protein OZF (ZNF146) is overexpressed in colorectal cancer". J. Pathol. 200 (2): 177–82. doi:10.1002/path.1337. PMID 12754738.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Antoine K, Ferbus D, Kolahgar G, et al. (2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1". J. Cell. Biochem. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID 15838871.
• Antoine K, Prosperi MT, Ferbus D, et al. (2005). "A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo". Mol. Cell. Biochem. 271 (1–2): 215–23. doi:10.1007/s11010-005-6417-2. PMID 15881673.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• ZNF146+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.