BLZF1

Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.[5][6]

BLZF1
Identifiers
Aliases	BLZF1, GOLGIN-45, JEM-1, JEM-1s, JEM1, basic leucine zipper nuclear factor 1
External IDs	OMIM: 608692 MGI: 1201607 HomoloGene: 31187 GeneCards: BLZF1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 169,367,970 bp[1] End 169,396,540 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.2 Start 164,289,800 bp[2] End 164,307,489 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • enzyme binding • DNA binding • GO:0001948 protein binding • ubiquitin protein ligase binding Cellular component • cytoplasm • Golgi lumen • cell nucleus • Golgi apparatus • Golgi membrane • membrane • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • Golgi to plasma membrane protein transport • protein transport • cellular proliferation • Golgi organization • regulation of cell growth • vesicle-mediated transport • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8548	66352
Ensembl	ENSG00000117475	ENSMUSG00000026577
UniProt	Q9H2G9 Q5T532	Q8R2X8
RefSeq (mRNA)	NM_003666 NM_001320972 NM_001320973	NM_001160208 NM_001160209 NM_025505 NM_001357052
RefSeq (protein)	NP_001307901 NP_001307902 NP_003657	NP_001153680 NP_001153681 NP_079781 NP_001343981
Location (UCSC)	Chr 1: 169.37 – 169.4 Mb	Chr 1: 164.29 – 164.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

BLZF1 has been shown to interact with GORASP2.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000117475 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026577 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Duprez E, Tong JH, Dérré J, Chen SJ, Berger R, Chen Z, Lanotte M (May 1997). "JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia". Oncogene. 14 (13): 1563–70. doi:10.1038/sj.onc.1200995. PMID 9129147.
6. "Entrez Gene: BLZF1 basic leucine zipper nuclear factor 1 (JEM-1)".
7. Barr FA, Preisinger C, Kopajtich R, Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol. Chem. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
• Tong JH, Fant X, Duprez E, Benoit G, Uphoff CC, Drexler HG, Pla JC, Lofvenberg E, Lanotte M (1998). "Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells". Leukemia. 12 (11): 1733–40. doi:10.1038/sj.leu.2401173. PMID 9823948.
• Tong JH, Duprez E, Lanotte M (1999). "JEM-1, a novel nuclear co-factor: localisation and functional interaction with AP-1". Leukemia. 13 (12): 1982–92. doi:10.1038/sj/leu/2401560. PMID 10602419.
• Tong JH, Fant X, Benoit G, Chen SJ, Chen Z, Lanotte M (2000). "Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: molecular cloning and analysis of its promoter region". Genomics. 69 (3): 380–90. doi:10.1006/geno.2000.6347. PMID 11056056.
• Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.
• Reichman TW, Muñiz LC, Mathews MB (2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Mol. Cell. Biol. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746.

External links

• BLZF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human BLZF1 genome location and BLZF1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.