Activating protein 2
Activating Protein 2 (AP-2) is a family of closely related transcription factors[1][2] which plays a critical role in regulating gene expression during early development.[3]
| transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | |
|---|---|
| Identifiers | |
| Symbol | TFAP2A |
| Alt. symbols | TFAP2, AP2TF |
| NCBI gene | 7020 |
| HGNC | 11742 |
| OMIM | 107580 |
| RefSeq | NM_003220 |
| UniProt | P05549 |
| Other data | |
| Locus | Chr. 6 p22.3 |
| transcription factor AP-2 beta (activating enhancer binding protein 2 beta) | |
|---|---|
| Identifiers | |
| Symbol | TFAP2B |
| Alt. symbols | AP2-B |
| NCBI gene | 7021 |
| HGNC | 11743 |
| OMIM | 601601 |
| RefSeq | NM_003221 |
| UniProt | Q92481 |
| Other data | |
| Locus | Chr. 6 p12 |
| transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | |
|---|---|
| Identifiers | |
| Symbol | TFAP2C |
| NCBI gene | 7022 |
| HGNC | 11744 |
| OMIM | 601602 |
| RefSeq | NM_003222 |
| UniProt | Q92754 |
| Other data | |
| Locus | Chr. 20 q13.2 |
| transcription factor AP-2 delta (activating enhancer binding protein 2 delta) | |
|---|---|
| Identifiers | |
| Symbol | TFAP2D |
| Alt. symbols | TFAP2BL1 |
| NCBI gene | 83741 |
| HGNC | 15581 |
| OMIM | 610161 |
| RefSeq | NM_172238 |
| UniProt | Q7Z6R9 |
| Other data | |
| Locus | Chr. 6 p12.3 |
| transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) | |
|---|---|
| Identifiers | |
| Symbol | TFAP2E |
| Alt. symbols | AP2E |
| NCBI gene | 339488 |
| HGNC | 30774 |
| RefSeq | NM_178548 |
| UniProt | Q6VUC0 |
| Other data | |
| Locus | Chr. 1 p34.3 |
References
- Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science. 251 (4997): 1067–71. doi:10.1126/science.1998122. PMID 1998122.
- Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". Genes Dev. 5 (4): 670–82. doi:10.1101/gad.5.4.670. PMID 2010091.
- Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control". Gene. 260 (1–2): 1–12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286.
External links
- Transcription+Factor+AP-2 at the US National Library of Medicine Medical Subject Headings (MeSH)
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