NFYB

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.[5][6]

NFYB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFYB, CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta
External IDsOMIM: 189904 MGI: 97317 HomoloGene: 38149 GeneCards: NFYB
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q23.3Start104,117,086 bp[1]
End104,138,241 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4801

18045

Ensembl

ENSG00000120837

ENSMUSG00000020248

UniProt

P25208

P63139

RefSeq (mRNA)

NM_006166

NM_010914

RefSeq (protein)

NP_006157
NP_006157.1

NP_035044

Location (UCSC)Chr 12: 104.12 – 104.14 MbChr 10: 82.75 – 82.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.[7]

Interactions

NFYB has been shown to interact with:

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References

  1. GRCh38: Ensembl release 89: ENSG00000120837 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020248 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics. 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067.
  6. Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci. 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081.
  7. "Entrez Gene: NFYB nuclear transcription factor Y, beta".
  8. Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi:10.1074/jbc.M101553200. PMID 11306579.
  9. Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC 231848. PMID 9032250.
  10. Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (Apr 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. PMID 11282029.
  11. Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (Jun 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC 146709. PMID 9153318.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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