HMG-box
In molecular biology, the HMG-box (high mobility group box) is a protein domain which is involved in DNA binding.[1]
| HMG (high mobility group) box | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 NMR structure of the HMG-box domain of the LEF1 protein (rainbow colored, N-terminus = blue, C-terminus = red) complexed with DNA (brown) based on the PDB: 2LEF coordinates. | |||||||||||
| Identifiers | |||||||||||
| Symbol | PF00505 | ||||||||||
| Pfam | PF00505 | ||||||||||
| InterPro | IPR009071 | ||||||||||
| SCOPe | 1hsm / SUPFAM | ||||||||||
| |||||||||||
Structure
The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right).[2]
Function
HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity.[1] HMG-box domains are found in high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin.[2] The single and the double box HMG proteins alter DNA architecture by inducing bends upon binding.[3][4]
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gollark: These backdoors are such wonderful debugging aids.
gollark: I forgot to ignore _G.
gollark: Er, basically, my sandboxing thing recursively descends the environment table to attempt to setfenv it...
gollark: Wow, I've created an amazing amount of errors so far!
References
- Stros M, Launholt D, Grasser KD (October 2007). "The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins". Cell. Mol. Life Sci. 64 (19–20): 2590–606. doi:10.1007/s00018-007-7162-3. PMID 17599239.
- Thomas JO (August 2001). "HMG1 and 2: architectural DNA-binding proteins". Biochem. Soc. Trans. 29 (Pt 4): 395–401. doi:10.1042/BST0290395. PMID 11497996.
- D. Murugesapillai et al, DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin, Nucleic Acids Res (2014) 42 (14): 8996-9004
- D. Murugesapillai et al, Single-molecule studies of high-mobility group B architectural DNA bending proteins, Biophys Rev (2016) doi:10.1007/s12551-016-0236-4
External links
- HMG-Box Domains at the US National Library of Medicine Medical Subject Headings (MeSH)
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