HES6

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.[5][6]

HES6
Identifiers
Aliases	HES6, C-HAIRY1, HES-6, bHLHb41, bHLHc23, hes family bHLH transcription factor 6
External IDs	OMIM: 610331 MGI: 1859852 HomoloGene: 23111 GeneCards: HES6
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 238,238,267 bp[1] End 238,240,662 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 91,411,483 bp[2] End 91,414,038 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • transcription factor binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein dimerization activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001104 transcription cofactor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001106 transcription corepressor activity • sequence-specific DNA binding • sequence-specific double-stranded DNA binding Cellular component • cell nucleus • transcription factor complex Biological process • regulation of transcription from RNA polymerase II promoter • multicellular organism development • cell differentiation • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • nervous system development • regulation of transcription, DNA-templated • somitogenesis • Notch signaling pathway • regulation of neurogenesis • anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55502	55927
Ensembl	ENSG00000144485	ENSMUSG00000067071
UniProt	Q96HZ4	Q9JHE6
RefSeq (mRNA)	NM_018645 NM_001142853 NM_001282434	NM_019479 NM_001360899 NM_001360900
RefSeq (protein)	NP_001136325 NP_001269363 NP_061115	NP_062352 NP_001347828 NP_001347829
Location (UCSC)	Chr 2: 238.24 – 238.24 Mb	Chr 1: 91.41 – 91.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

HES6 has been shown to interact with TLE1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000144485 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067071 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. PMID 10851137.
6. "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".
7. Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.

Further reading

• Bech P, Bolwig TG, Dein E, Jacobsen O, Gram LF (1975). "Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale". Acta Psychiatr Scand. 52 (1): 1–6. doi:10.1111/j.1600-0447.1975.tb00017.x. PMID 1155198.
• Vasiliauskas D, Stern CD (2000). "Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors". Mech. Dev. 98 (1–2): 133–7. doi:10.1016/S0925-4773(00)00443-3. PMID 11044617.
• Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.
• Swearingen ML, Sun D, Bourner M, Weinstein EJ (2003). "Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array". Cancer Lett. 198 (2): 229–39. doi:10.1016/S0304-3835(03)00313-6. PMID 12957362.
• Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMC 193938. PMID 12972610.
• Kang SA, Seol JH, Kim J (2005). "The conserved WRPW motif of Hes6 mediates proteasomal degradation". Biochem. Biophys. Res. Commun. 332 (1): 33–6. doi:10.1016/j.bbrc.2005.04.089. PMID 15896295.
• Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F (2007). "HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion". Biochem. Biophys. Res. Commun. 355 (2): 331–7. doi:10.1016/j.bbrc.2007.01.153. PMC 1852427. PMID 17300753.
• Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D (2007). "Impaired expression of Notch signaling genes in aged human skeletal muscle". J. Gerontol. A Biol. Sci. Med. Sci. 62 (1): 9–17. CiteSeerX 10.1.1.499.7911. doi:10.1093/gerona/62.1.9. PMID 17301032.
• Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells". FEBS Lett. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772.

External links

• HES6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.