HLF (gene)

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[5][6]

HLF
Identifiers
Aliases	HLF, PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
External IDs	OMIM: 142385 MGI: 96108 HomoloGene: 31074 GeneCards: HLF
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 55,264,960 bp[1] End 55,325,187 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 55.03 cM Start 90,336,536 bp[2] End 90,390,895 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • double-stranded DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • DNA binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • multicellular organism development • skeletal muscle cell differentiation • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated • rhythmic process • positive regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3131	217082
Ensembl	ENSG00000108924	ENSMUSG00000003949
UniProt	Q16534	Q8BW74
RefSeq (mRNA)	NM_002126 NM_001330375	NM_172563
RefSeq (protein)	NP_001317304 NP_002117	NP_766151
Location (UCSC)	Chr 17: 55.26 – 55.33 Mb	Chr 11: 90.34 – 90.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000108924 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003949 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. doi:10.1126/science.1386162. PMID 1386162.
6. "Entrez Gene: HLF hepatic leukemia factor".

Further reading

• LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human leukemia". Frontiers in Bioscience. 8: s206-22. doi:10.2741/1030. PMID 12700034.
• Hunger SP, Ohyashiki K, Toyama K, Cleary ML (September 1992). "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia". Genes & Development. 6 (9): 1608–20. doi:10.1101/gad.6.9.1608. PMID 1516826.
• Falvey E, Fleury-Olela F, Schibler U (September 1995). "The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences". The EMBO Journal. 14 (17): 4307–17. doi:10.1002/j.1460-2075.1995.tb00105.x. PMC 394515. PMID 7556072.
• Hunger SP, Brown R, Cleary ML (September 1994). "DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF". Molecular and Cellular Biology. 14 (9): 5986–96. doi:10.1128/mcb.14.9.5986. PMC 359124. PMID 8065331.
• Inaba T, Shapiro LH, Funabiki T, Sinclair AE, Jones BG, Ashmun RA, Look AT (May 1994). "DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein". Molecular and Cellular Biology. 14 (5): 3403–13. doi:10.1128/mcb.14.5.3403. PMC 358705. PMID 8164688.
• Hunger SP (February 1996). "Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis". Blood. 87 (4): 1211–24. doi:10.1182/blood.v87.4.1211.bloodjournal8741211. PMID 8608207.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Hunger SP, Li S, Fall MZ, Naumovski L, Cleary ML (June 1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties". Blood. 87 (11): 4607–17. PMID 8639829.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y (July 1998). "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock". Biochemical and Biophysical Research Communications. 248 (3): 789–94. doi:10.1006/bbrc.1998.9012. PMID 9704006.
• Inukai T, Inaba T, Ikushima S, Look AT (October 1998). "The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF". Molecular and Cellular Biology. 18 (10): 6035–43. doi:10.1128/mcb.18.10.6035. PMC 109189. PMID 9742120.
• Begbie M, Mueller C, Lillicrap D (February 1999). "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes". DNA and Cell Biology. 18 (2): 165–73. doi:10.1089/104454999315556. PMID 10073576.
• Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y (April 1999). "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300". The EMBO Journal. 18 (7): 1905–14. doi:10.1093/emboj/18.7.1905. PMC 1171276. PMID 10202154.
• Honda H, Inaba T, Suzuki T, Oda H, Ebihara Y, Tsuiji K, Nakahata T, Ishikawa T, Yazaki Y, Hirai H (May 1999). "Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia". Blood. 93 (9): 2780–90. doi:10.1182/blood.v93.9.2780.409a47_2780_2790. PMID 10216071.
• Matsunaga T, Inaba T, Matsui H, Okuya M, Miyajima A, Inukai T, Funabiki T, Endo M, Look AT, Kurosawa H (April 2004). "Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein". Blood. 103 (8): 3185–91. doi:10.1182/blood-2003-09-3022. PMID 15070701.

External links

• HLF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.