HOXD11

Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.[5][6][7]

HOXD11
Identifiers
Aliases	HOXD11, HOX4, HOX4F, homeobox D11
External IDs	OMIM: 142986 MGI: 96203 HomoloGene: 7368 GeneCards: HOXD11
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 176,104,216 bp[1] End 176,109,754 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 44.13 cM Start 74,679,557 bp[2] End 74,687,016 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm Biological process • multicellular organism development • branching involved in ureteric bud morphogenesis • regulation of transcription, DNA-templated • dorsal/ventral pattern formation • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3237	15431
Ensembl	ENSG00000128713	ENSMUSG00000042499
UniProt	P31277	P23813
RefSeq (mRNA)	NM_021192	NM_008273
RefSeq (protein)	NP_067015	NP_032299
Location (UCSC)	Chr 2: 176.1 – 176.11 Mb	Chr 2: 74.68 – 74.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.[7] [8][9][10]

See also

• Homeobox

References

1. GRCh38: Ensembl release 89: ENSG00000128713 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042499 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
6. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
7. "Entrez Gene: HOXD11 homeobox D11".
8. Davis AP, Capecchi MR (1 August 1994). "Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11". Development. 120 (8): 2187–98. PMID 7925020.
9. Davis AP, Witte DP, Hsieh-Li HM, Potter SS, Capecchi MR (June 1995). "Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11". Nature. 375 (6534): 791–5. doi:10.1038/375791a0. PMID 7596412.
10. Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development. 122 (4): 1175–85. PMID 8620844.

Further reading

• Johnson RL, Tabin CJ (1997). "Molecular models for vertebrate limb development". Cell. 90 (6): 979–90. doi:10.1016/S0092-8674(00)80364-5. PMID 9323126.
• Goodman FR (2003). "Limb malformations and the human HOX genes". Am. J. Med. Genet. 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469.
• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Shen WF, Montgomery JC, Rozenfeld S, et al. (1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Mol. Cell. Biol. 17 (11): 6448–58. doi:10.1128/MCB.17.11.6448. PMC 232497. PMID 9343407.
• Hérault Y, Beckers J, Gérard M, Duboule D (1999). "Hox gene expression in limbs: colinearity by opposite regulatory controls". Dev. Biol. 208 (1): 157–65. doi:10.1006/dbio.1998.9179. PMID 10075849.
• Del Campo M, Jones MC, Veraksa AN, et al. (1999). "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". Am. J. Hum. Genet. 65 (1): 104–10. doi:10.1086/302467. PMC 1378080. PMID 10364522.
• Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1–2): 151–3. doi:10.1159/000015651. PMID 11060466.
• Patterson LT, Pembaur M, Potter SS (2001). "Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney". Development. 128 (11): 2153–61. PMID 11493536.
• Goodman FR, Majewski F, Collins AL, Scambler PJ (2002). "A 117-kb Microdeletion Removing HOXD9–HOXD13 and EVX2 Causes Synpolydactyly". Am. J. Hum. Genet. 70 (2): 547–55. doi:10.1086/338921. PMC 384929. PMID 11778160.
• Taketani T, Taki T, Shibuya N, et al. (2002). "The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15)". Cancer Res. 62 (1): 33–7. PMID 11782354.
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Boulet AM, Capecchi MR (2002). "Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse". Dev. Biol. 249 (1): 96–107. doi:10.1006/dbio.2002.0755. PMID 12217321.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhao X, Sun M, Zhao J, et al. (2007). "Mutations in HOXD13 Underlie Syndactyly Type V and a Novel Brachydactyly-Syndactyly Syndrome". Am. J. Hum. Genet. 80 (2): 361–71. doi:10.1086/511387. PMC 1785357. PMID 17236141.

External links

• HOXD11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.