ETV4

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.[5][6][7]

ETV4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesETV4, E1A-F, E1AF, PEA3, PEAS3, ETS variant 4, ETS variant transcription factor 4
External IDsOMIM: 600711 MGI: 99423 HomoloGene: 1504 GeneCards: ETV4
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.31Start43,527,844 bp[1]
End43,579,620 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2118

18612

Ensembl

ENSG00000175832

ENSMUSG00000017724

UniProt

P43268

P28322

RefSeq (mRNA)

NM_008815
NM_001316365
NM_001316366

RefSeq (protein)

NP_001303294
NP_001303295
NP_032841

Location (UCSC)Chr 17: 43.53 – 43.58 MbChr 11: 101.77 – 101.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disease marker

Two variants of a disease associated with ETV4 is Ewing Sarcoma and Extraosseous Ewing's Sarcoma. While both are cancerous tumors, the former grows in the bones most commonly affecting the arms, legs, hips, and spine, while the later affects the soft tissue in the chest, foot, pelvis and spine.

gollark: KST.
gollark: A thing you can do is claim large random wilderness and `/transferclaim` it to people to fill their claimblocks.
gollark: `/kit gp` with giant armies.
gollark: Oh, another use: transporting items in bulk via /home and stuff.
gollark: Well, sure, in that case...

References

  1. GRCh38: Ensembl release 89: ENSG00000175832 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017724 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Jul 1995). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics. 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID 8530053.
  6. "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)".
  7. "ETV4 Gene - GeneCards | ETV4 Protein | ETV4 Antibody". www.genecards.org. Retrieved 2019-10-20.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.