HMOX1

HMOX1 (heme oxygenase (decycling) 1) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase mediates the first step of heme catabolism, it cleaves heme to form biliverdin.

HMOX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM, 4WD4, 5BTQ
Identifiers
Aliases	HMOX1, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
External IDs	OMIM: 141250 MGI: 96163 HomoloGene: 31075 GeneCards: HMOX1
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 35,380,361 bp[1] End 35,394,207 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 35.59 cM|8 C1 Start 75,093,621 bp[2] End 75,100,589 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phospholipase D activity • protein homodimerization activity • heme oxygenase (decyclizing) activity • metal ion binding • signal transducer activity • heme binding • GO:0001948 protein binding • enzyme binding • oxidoreductase activity Cellular component • cytosol • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • nucleolus • endoplasmic reticulum • caveola • perinuclear region of cytoplasm • cell nucleus • extracellular Biological process • negative regulation of neuron apoptotic process • apoptotic process • cellular iron ion homeostasis • negative regulation of smooth muscle cell proliferation • cellular response to heat • GO:0007243 intracellular signal transduction • negative regulation of mast cell cytokine production • response to hypoxia • excretion • low-density lipoprotein particle clearance • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • positive regulation of chemokine biosynthetic process • small GTPase mediated signal transduction • negative regulation of DNA binding • response to nicotine • iron ion homeostasis • cell death • heme oxidation • negative regulation of mast cell degranulation • cellular response to cadmium ion • regulation of angiogenesis • negative regulation of muscle cell apoptotic process • response to oxidative stress • negative regulation of sequence-specific DNA binding transcription factor activity • cellular response to nutrient • positive regulation of angiogenesis • response to estrogen • wound healing involved in inflammatory response • regulation of blood pressure • heme catabolic process • erythrocyte homeostasis • regulation of sequence-specific DNA binding transcription factor activity • cellular response to arsenic-containing substance • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • angiogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • endothelial cell proliferation • positive regulation of I-kappaB kinase/NF-kappaB signaling • smooth muscle hyperplasia • protein homooligomerization • oxidation-reduction process • negative regulation of leukocyte migration • cellular response to hypoxia • response to hydrogen peroxide • negative regulation of cell proliferation • heme metabolic process • positive regulation of smooth muscle cell proliferation • regulation of transcription from RNA polymerase II promoter in response to iron • positive regulation of apoptotic process • cellular response to cisplatin • positive regulation of macroautophagy • negative regulation of vascular smooth muscle cell proliferation • negative regulation of epithelial cell apoptotic process • liver regeneration • negative regulation of macroautophagy • positive regulation of blood vessel diameter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3162	15368
Ensembl	ENSG00000100292	ENSMUSG00000005413
UniProt	P09601	P14901
RefSeq (mRNA)	NM_002133	NM_010442
RefSeq (protein)	NP_002124	NP_034572
Location (UCSC)	Chr 22: 35.38 – 35.39 Mb	Chr 8: 75.09 – 75.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, carbon monoxide, and ferrous iron.[5] The biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.[6]

The HMOX gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748.

Related conditions

• Heme oxygenase-1 deficiency

Anti-inflammatory effect

The ability of oxygenase 1 to catabolize free heme and produce carbon monoxide (CO) gives its anti-inflammatory properties by up-regulation of interleukin 10 (IL-10) and interleukin 1 receptor antagonist (IL-1RA) expression.[7]

See also

• HMOX2
• Focal segmental glomerulosclerosis

References

1. GRCh38: Ensembl release 89: ENSG00000100292 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005413 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lehninger's Principles of Biochemistry, 5th Edition. New York: W.H. Freeman and Company. 2008. pp. 876. ISBN 978-0-7167-7108-1.
6. "Entrez Gene: HMOX1 heme oxygenase (decycling) 1".
7. Piantadosi CA, Withers CM, Bartz RR, MacGarvey NC, Fu P, Sweeney TE, Welty-Wolf KE, Suliman HB (May 2011). "Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression". J. Biol. Chem. 286 (18): 16374–85. doi:10.1074/jbc.M110.207738. PMC 3091243. PMID 21454555.

Further reading

• Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S (1999). "Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency". J Clin Invest. 103 (1): 129–35. doi:10.1172/JCI4165. PMC 407858. PMID 9884342.
• Zhang Z, Song Y, Zhang Z, Li D, Zhu H, Liang R, Gu Y, Pang Y, Qi J, Wu H, Wang J (2016). "Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice". J Cereb Blood Flow Metab. 37 (1): 25–38. doi:10.1177/0271678X16655814. PMC 5363754. PMID 27317654.
• Wang J, Doré S (2007). "Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage". Brain. 130 (6): 1643–52. doi:10.1093/brain/awm095. PMC 2291147. PMID 17525142.
• Soares MP, Brouard S, Smith RN, Bach FH (2002). "Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs". Immunol. Rev. 184: 275–85. doi:10.1034/j.1600-065x.2001.1840124.x. PMID 12086318.
• Morse D, Choi AM (2002). "Heme oxygenase-1: the "emerging molecule" has arrived". Am. J. Respir. Cell Mol. Biol. 27 (1): 8–16. doi:10.1165/ajrcmb.27.1.4862. PMID 12091240.
• Buelow R, Tullius SG, Volk HD (2002). "Protection of grafts by hemoxygenase-1 and its toxic product carbon monoxide". Am. J. Transplant. 1 (4): 313–5. doi:10.1034/j.1600-6143.2001.10404.x. PMID 12099373.
• Ishikawa K (2003). "Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders". Curr. Pharm. Des. 9 (30): 2489–97. doi:10.2174/1381612033453767. PMID 14529548.
• Exner M, Minar E, Wagner O, Schillinger M (2005). "The role of heme oxygenase-1 promoter polymorphisms in human disease". Free Radic. Biol. Med. 37 (8): 1097–104. doi:10.1016/j.freeradbiomed.2004.07.008. PMID 15451051.
• Ozono R (2006). "New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway". Current Pharmaceutical Biotechnology. 7 (2): 87–93. doi:10.2174/138920106776597630. PMID 16724942.
• Tracz MJ, Alam J, Nath KA (2007). "Physiology and pathophysiology of heme: implications for kidney disease". J. Am. Soc. Nephrol. 18 (2): 414–20. doi:10.1681/ASN.2006080894. PMID 17229906.
• Chang CF, Cho S, Wang J (2014). "(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways". Ann Clin Transl Neurol. 1 (4): 258–271. doi:10.1002/acn3.54. PMC 3984761. PMID 24741667.
• Hill-Kapturczak N, Agarwal A (2007). "Haem oxygenase-1--a culprit in vascular and renal damage?". Nephrol. Dial. Transplant. 22 (6): 1495–9. doi:10.1093/ndt/gfm093. PMID 17389623.

External links

• Overview of all the structural information available in the PDB for UniProt: P09601 (Heme oxygenase 1) at the PDBe-KB.