NFE2

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.[5][6]

NFE2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFE2, NF-E2, p45, nuclear factor, erythroid 2
External IDsOMIM: 601490 MGI: 97308 HomoloGene: 4491 GeneCards: NFE2
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.13Start54,292,111 bp[1]
End54,301,015 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4778

18022

Ensembl

ENSG00000123405

ENSMUSG00000058794

UniProt

Q16621

Q07279

RefSeq (mRNA)

NM_001136023
NM_001261461
NM_006163

RefSeq (protein)

NP_001129495
NP_001248390
NP_006154

Location (UCSC)Chr 12: 54.29 – 54.3 MbChr 15: 103.25 – 103.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is involved in megakaryocyte production.[7]

Interactions

NFE2 has been shown to interact with CREB-binding protein.[8]

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References

  1. GRCh38: Ensembl release 89: ENSG00000123405 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000058794 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol. 13 (9): 5604–12. doi:10.1128/mcb.13.9.5604. PMC 360284. PMID 8355703.
  6. "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".
  7. Gasiorek JJ, Blank V (2015). "Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells". Cellular and Molecular Life Sciences. 72 (12): 2323–2335. doi:10.1007/s00018-015-1866-6. PMID 25721735.
  8. Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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