BHLHB2

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.[5][6][7][8]

BHLHE40
Identifiers
Aliases	BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14, basic helix-loop-helix family member e40, Clast5, SHARP2
External IDs	OMIM: 604256 MGI: 1097714 HomoloGene: 2722 GeneCards: BHLHE40
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p26.1 Start 4,979,437 bp[1] End 4,985,323 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E2 Start 108,660,629 bp[2] End 108,666,925 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • protein dimerization activity • protein homodimerization activity • MRF binding • GO:0001106 transcription corepressor activity • protein domain specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • RNA polymerase II activating transcription factor binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • bHLH transcription factor binding • E-box binding • GO:0001948 protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transcription factor binding • sequence-specific DNA binding • sequence-specific double-stranded DNA binding Cellular component • cytoplasm • cell nucleus • nuclear body Biological process • regulation of transcription, DNA-templated • response to light stimulus • rhythmic process • negative regulation of transcription from RNA polymerase II promoter • circadian regulation of gene expression • transcription, DNA-templated • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription, DNA-templated • entrainment of circadian clock by photoperiod • circadian rhythm • somitogenesis • Notch signaling pathway • cell differentiation • regulation of neurogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8553	20893
Ensembl	ENSG00000134107	ENSMUSG00000030103
UniProt	O14503	O35185
RefSeq (mRNA)	NM_003670	NM_011498
RefSeq (protein)	NP_003661	NP_035628
Location (UCSC)	Chr 3: 4.98 – 4.99 Mb	Chr 6: 108.66 – 108.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000134107 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030103 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M, Kato Y (Jul 1997). "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes". Biochemical and Biophysical Research Communications. 236 (2): 294–8. doi:10.1006/bbrc.1997.6960. PMID 9240428.
6. Antonevich T, Taneja R (Oct 1999). "Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 254–5. doi:10.1159/000015305. PMID 10449910.
7. Stevens JD, Roalson EH, Skinner MK (Nov 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation; Research in Biological Diversity. 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763.
8. "Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2".

Further reading

• Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, Tsutsumi S, Kawamoto T, Iwamoto Y, Kato Y (Mar 2001). "Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2". Journal of Biochemistry. 129 (3): 391–6. doi:10.1093/oxfordjournals.jbchem.a002869. PMID 11226878.
• Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (May 2001). "Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway". The Journal of Biological Chemistry. 276 (18): 15306–15. doi:10.1074/jbc.M010516200. PMID 11278694.
• Sun H, Lu B, Li RQ, Flavell RA, Taneja R (Nov 2001). "Defective T cell activation and autoimmune disorder in Stra13-deficient mice". Nature Immunology. 2 (11): 1040–7. doi:10.1038/ni721. PMID 11668339.
• Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O (Nov 2001). "Identification of genes differentially induced by hypoxia in pancreatic cancer cells". Biochemical and Biophysical Research Communications. 288 (4): 882–6. doi:10.1006/bbrc.2001.5867. PMID 11688991.
• Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, Wan Y, Yan B (Oct 2002). "Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation". The Biochemical Journal. 367 (Pt 2): 413–22. doi:10.1042/BJ20020514. PMC 1222902. PMID 12119049.
• St-Pierre B, Flock G, Zacksenhaus E, Egan SE (Nov 2002). "Stra13 homodimers repress transcription through class B E-box elements". The Journal of Biological Chemistry. 277 (48): 46544–51. doi:10.1074/jbc.M111652200. PMID 12297495.
• Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y (Dec 2002). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes". The Journal of Biological Chemistry. 277 (49): 47014–21. doi:10.1074/jbc.M204938200. PMID 12354771.
• Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y (Dec 2002). "Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages". The Journal of Biological Chemistry. 277 (51): 50112–20. doi:10.1074/jbc.M206771200. PMID 12384505.
• Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K (Oct 2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock". Nature. 419 (6909): 841–4. doi:10.1038/nature01123. PMID 12397359.
• Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B (May 2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter". The Journal of Biological Chemistry. 278 (19): 16899–907. doi:10.1074/jbc.M300596200. PMID 12624110.
• Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, Harris AL (Jun 2003). "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer". The Journal of Pathology. 200 (2): 222–8. doi:10.1002/path.1330. PMID 12754744.
• Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI (Jul 2004). "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets". Journal of Molecular Biology. 340 (4): 641–53. doi:10.1016/j.jmb.2004.05.025. PMID 15223310.
• Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y (Nov 2004). "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1". European Journal of Biochemistry / FEBS. 271 (22): 4409–19. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782.
• Ivanova AV, Ivanov SV, Lerman ML (Feb 2005). "Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins". Cellular and Molecular Life Sciences. 62 (4): 471–84. doi:10.1007/s00018-004-4423-2. PMID 15719173.
• Ivanova A, Liao SY, Lerman MI, Ivanov S, Stanbridge EJ (Jul 2005). "STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker". Journal of Medical Genetics. 42 (7): 565–76. doi:10.1136/jmg.2004.029835. PMC 1736099. PMID 15994878.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.

External links

• BHLHB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook BHLHE40
• Human BHLHE40 genome location and BHLHE40 gene details page in the UCSC Genome Browser.
• Human DEC1 genome location and DEC1 gene details page in the UCSC Genome Browser.
• Human STRA13 genome location and STRA13 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.