KLF12

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[5][6]

KLF12
Identifiers
AliasesKLF12, AP-2rep, AP2REP, HSPC122, Kruppel-like factor 12, Kruppel like factor 12
External IDsOMIM: 607531 MGI: 1333796 HomoloGene: 21417 GeneCards: KLF12
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q22.1Start73,686,089 bp[1]
End73,995,056 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11278

16597

Ensembl

ENSG00000118922

ENSMUSG00000072294

UniProt

Q9Y4X4

O35738

RefSeq (mRNA)

NM_007249
NM_016285

NM_010636

RefSeq (protein)

NP_009180

NP_034766

Location (UCSC)Chr 13: 73.69 – 74 MbChr 14: 99.87 – 100.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000118922 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000072294 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics. 63 (3): 384–90. doi:10.1006/geno.1999.6084. PMID 10704285.
  6. "Entrez Gene: KLF12 Kruppel-like factor 12".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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