LMO1

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.[5][6][7]

LMO1
Identifiers
Aliases	LMO1, RBTN1, RHOM1, TTG1, LIM domain only 1
External IDs	OMIM: 186921 MGI: 102812 HomoloGene: 48101 GeneCards: LMO1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 8,224,309 bp[1] End 8,268,716 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E3|7 57.21 cM Start 109,138,572 bp[2] End 109,175,207 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding Cellular component • cell nucleus • nucleoplasm Biological process • regulation of T cell homeostatic proliferation • negative regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4004	109594
Ensembl	ENSG00000166407	ENSMUSG00000036111
UniProt	P25800	Q924W9
RefSeq (mRNA)	NM_001270428 NM_002315	NM_001302205 NM_001302206 NM_057173 NM_001382564
RefSeq (protein)	NP_001257357 NP_002306	NP_001289134 NP_001289135 NP_476514 NP_001369493
Location (UCSC)	Chr 11: 8.22 – 8.27 Mb	Chr 7: 109.14 – 109.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[7]

Interactions

LMO1 has been shown to interact with GATA3[8][9] and TAL1.[10][11]

References

1. GRCh38: Ensembl release 89: ENSG00000166407 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036111 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc Natl Acad Sci U S A. 88 (10): 4367–71. Bibcode:1991PNAS...88.4367B. doi:10.1073/pnas.88.10.4367. PMC 51660. PMID 2034676.
6. McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells". Blood. 77 (3): 599–606. doi:10.1182/blood.V77.3.599.599. PMID 1703797.
7. "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)".
8. Ono, Y; Fukuhara N; Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. 18 (12): 6939–50. doi:10.1128/MCB.18.12.6939. ISSN 0270-7306. PMC 109277. PMID 9819382.
9. Ono, Y; Fukuhara N; Yoshie O (February 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. 272 (7): 4576–81. doi:10.1074/jbc.272.7.4576. ISSN 0021-9258. PMID 9020185.
10. Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. ISSN 0027-8424. PMC 44657. PMID 8078932.
11. Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. ISSN 0261-4189. PMC 395422. PMID 7957052.

Further reading

• Foroni L, Boehm T, White L, et al. (1992). "The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development". J. Mol. Biol. 226 (3): 747–61. doi:10.1016/0022-2836(92)90630-3. PMID 1507224.
• Boehm T, Spillantini MG, Sofroniew MV, et al. (1991). "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression". Oncogene. 6 (5): 695–703. PMID 2052354.
• Chen Q, Cheng JT, Tasi LH, et al. (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein". EMBO J. 9 (2): 415–24. doi:10.1002/j.1460-2075.1990.tb08126.x. PMC 551682. PMID 2303035.
• Boehm T, Greenberg JM, Buluwela L, et al. (1990). "An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs". EMBO J. 9 (3): 857–68. doi:10.1002/j.1460-2075.1990.tb08183.x. PMC 551746. PMID 2311586.
• McGuire EA, Hockett RD, Pollock KM, et al. (1989). "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein". Mol. Cell. Biol. 9 (5): 2124–32. doi:10.1128/MCB.9.5.2124. PMC 363006. PMID 2501659.
• Boehm T, Baer R, Lavenir I, et al. (1988). "The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15". EMBO J. 7 (2): 385–94. doi:10.1002/j.1460-2075.1988.tb02825.x. PMC 454331. PMID 3259177.
• Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
• Valge-Archer VE, Osada H, Warren AJ, et al. (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
• Arber S, Caroni P (1996). "Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ". Genes Dev. 10 (3): 289–300. doi:10.1101/gad.10.3.289. PMID 8595880.
• Jurata LW, Kenny DA, Gill GN (1996). "Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11693–8. Bibcode:1996PNAS...9311693J. doi:10.1073/pnas.93.21.11693. PMC 38120. PMID 8876198.
• Ono Y, Fukuhara N, Yoshie O (1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. 272 (7): 4576–81. doi:10.1074/jbc.272.7.4576. PMID 9020185.
• Valge-Archer V, Forster A, Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)". Oncogene. 17 (24): 3199–202. doi:10.1038/sj.onc.1202353. PMID 9872335.
• Bao J, Talmage DA, Role LW, Gautier J (2000). "Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins". Development. 127 (2): 425–35. PMID 10603358.
• Cichutek A, Brueckmann T, Seipel B, et al. (2001). "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)". Cytogenet. Cell Genet. 93 (3–4): 277–83. doi:10.1159/000056998. PMID 11528126.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lin YW, Deveney R, Barbara M, et al. (2005). "OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1". Cancer Res. 65 (16): 7151–8. doi:10.1158/0008-5472.CAN-05-1400. PMC 1681523. PMID 16103065.
• Saeki N, Kim DH, Usui T, et al. (2007). "GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling". Oncogene. 26 (45): 6488–98. doi:10.1038/sj.onc.1210475. PMID 17471240.