RBPJ

Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.[5][6][7]

RBPJ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F8X, 3NBN, 3V79
Identifiers
Aliases	RBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1
External IDs	OMIM: 147183 MGI: 96522 HomoloGene: 7511 GeneCards: RBPJ
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 26,163,455 bp[1] End 26,435,131 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C1|5 29.37 cM Start 53,466,152 bp[2] End 53,657,362 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein N-terminus binding • RNA polymerase II repressing transcription factor binding • GO:0001948 protein binding • recombinase activity • chromatin binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • repressing transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nucleolus • MAML1-RBP-Jkappa- ICN1 complex • transcription factor complex • cytoplasm • cell nucleus • nucleoplasm • transcriptional repressor complex Biological process • artery morphogenesis • regulation of transcription from RNA polymerase II promoter • neuron differentiation • epidermal cell fate specification • positive regulation of cell proliferation • Clara cell differentiation • interleukin-4 secretion • somatic stem cell population maintenance • endocardium development • cell fate commitment • DNA recombination • somitogenesis • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • defense response to bacterium • regulation of timing of cell differentiation • regulation of transcription, DNA-templated • humoral immune response • keratinocyte differentiation • hair follicle maturation • negative regulation of cell proliferation • pituitary gland development • negative regulation of cell differentiation • Notch signaling involved in heart development • transcription, DNA-templated • positive regulation of gene expression • arterial endothelial cell fate commitment • myeloid dendritic cell differentiation • blood vessel remodeling • secondary heart field specification • regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • sebaceous gland development • positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • inflammatory response to antigenic stimulus • heart development • auditory receptor cell fate commitment • B cell differentiation • regulation of gene expression • Notch signaling pathway • dorsal aorta morphogenesis • atrioventricular canal development • positive regulation of ephrin receptor signaling pathway • epithelial to mesenchymal transition involved in endocardial cushion formation • outflow tract morphogenesis • cardiac left ventricle morphogenesis • negative regulation of transcription from RNA polymerase II promoter • labyrinthine layer blood vessel development • blood vessel lumenization • endocardium morphogenesis • ventricular trabecula myocardium morphogenesis • negative regulation of ossification • positive regulation of cell proliferation involved in heart morphogenesis • regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation • positive regulation of cardiac muscle cell proliferation • angiogenesis • epithelial to mesenchymal transition • positive regulation of BMP signaling pathway • positive regulation of ERBB signaling pathway • blood vessel endothelial cell fate specification • negative regulation of transcription, DNA-templated • positive regulation of transcription of Notch receptor target • positive regulation of Notch signaling pathway • haematopoiesis • aortic valve development • pulmonary valve development • ventricular septum morphogenesis • negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3516	19664
Ensembl	ENSG00000168214	ENSMUSG00000039191
UniProt	Q06330	P31266
RefSeq (mRNA)	NM_005349 NM_015874 NM_203283 NM_203284 NM_001363577 NM_001374400 NM_001374401 NM_001374402 NM_001374403 NM_001379406 NM_001379407 NM_001379408 NM_001379409	NM_001080927 NM_001080928 NM_001277116 NM_009035 NM_001359152
RefSeq (protein)	NP_005340 NP_056958 NP_976028 NP_976029 NP_001350506 NP_001361329 NP_001361330 NP_001361331 NP_001361332 NP_001366335 NP_001366336 NP_001366337 NP_001366338	NP_001074396 NP_001074397 NP_001264045 NP_033061 NP_001346081
Location (UCSC)	Chr 4: 26.16 – 26.44 Mb	Chr 5: 53.47 – 53.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

RBPJ[8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.[9]

Interactions

RBPJ has been shown to interact with:

• NOTCH1[10][11]
• NCOR2,[12][13]
• PCAF,[14]
• SND1,[15][16] and
• SNW1.[15][17]

References

1. GRCh38: Ensembl release 89: ENSG00000168214 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039191 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, Kawaichi M, Honjo T (Aug 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics. 17 (2): 306–15. doi:10.1006/geno.1993.1326. PMID 8406481.
6. Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK (Jun 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics. 42 (2): 337–41. doi:10.1007/BF02766956. PMID 9290259.
7. "NCBI Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".
8. "HGNC: RBPJ Symbol Report".
9. Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD (Mar 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology. 16 (3): 952–9. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.
10. Nam Y, Weng AP, Aster JC, Blacklow SC (Jun 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.
11. Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (Apr 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040.
12. Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.
13. Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–32. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
14. Kurooka H, Honjo T (Jun 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–20. doi:10.1074/jbc.M000909200. PMID 10747963.
15. Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
16. Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
17. Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.

Further reading

• Oka C, Kawaichi M (1995). "V(D)J recombination of immunoglobulin genes". Advances in Biophysics. 31: 163–80. doi:10.1016/0065-227X(95)99390-B. PMID 7625272.
• Matsunami N, Hamaguchi Y, Yamamoto Y, Kuze K, Kangawa K, Matsuo H, Kawaichi M, Honjo T (1990). "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif". Nature. 342 (6252): 934–7. doi:10.1038/342934a0. PMID 2556644.
• Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (Sep 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology. 15 (9): 4735–44. doi:10.1128/mcb.15.9.4735. PMC 230717. PMID 7651391.
• Zhao B, Marshall DR, Sample CE (Jul 1996). "A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa". Journal of Virology. 70 (7): 4228–36. PMC 190353. PMID 8676443.
• Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T (Dec 1995). "Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)". Current Biology. 5 (12): 1416–23. doi:10.1016/S0960-9822(95)00279-X. hdl:2433/202204. PMID 8749394.
• Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H (Oct 1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
• Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (Mar 1997). "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation". Journal of Virology. 71 (3): 1938–45. PMC 191274. PMID 9032325.
• Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (Apr 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040.
• Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T (Aug 1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway". Genes & Development. 12 (15): 2269–77. doi:10.1101/gad.12.15.2269. PMC 317043. PMID 9694793.
• Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Callahan J, Aster J, Sklar J, Kieff E, Robertson ES (Jan 2000). "Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells". Leukemia. 14 (1): 84–92. doi:10.1038/sj.leu.2401630. PMID 10637481.
• Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, Karran L, Wang Y, Hayward SD, Farrell PJ (Apr 2000). "Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus". Journal of Virology. 74 (7): 3082–92. doi:10.1128/JVI.74.7.3082-3092.2000. PMC 111807. PMID 10708423.
• Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–10. doi:10.1128/MCB.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
• Kurooka H, Honjo T (Jun 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–20. doi:10.1074/jbc.M000909200. PMID 10747963.
• Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/S0925-4773(01)00373-2. PMID 11404076.
• Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–32. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665.

External links

• RBPJ+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.