NKX2-2

Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.[5][6][7]

NKX2-2
Identifiers
Aliases	NKX2-2, NKX2.2, NKX2B, NK2 homeobox 2
External IDs	OMIM: 604612 MGI: 97347 HomoloGene: 1879 GeneCards: NKX2-2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.22 Start 21,511,017 bp[1] End 21,514,064 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G2|2 72.63 cM Start 147,177,546 bp[2] End 147,194,243 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • chromatin binding • GO:0001105 transcription coactivator activity • GO:0001158 core promoter proximal region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component • intracellular • nucleoplasm • cell nucleus Biological process • positive regulation of oligodendrocyte differentiation • cell differentiation • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • pancreatic PP cell fate commitment • response to organic cyclic compound • cell development • spinal cord oligodendrocyte cell fate specification • response to progesterone • neuron fate specification • response to glucose • transcription, DNA-templated • nervous system development • multicellular organism development • brain development • astrocyte differentiation • positive regulation of gene expression • positive regulation of neuron differentiation • positive regulation of cell differentiation • regulation of cell differentiation • smoothened signaling pathway • oligodendrocyte development • spinal cord motor neuron differentiation • digestive tract development • pancreatic A cell fate commitment • type B pancreatic cell fate commitment • ventral spinal cord interneuron fate determination • type B pancreatic cell development • spinal cord oligodendrocyte cell differentiation • optic nerve development • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • endocrine pancreas development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4821	18088
Ensembl	ENSG00000125820	ENSMUSG00000027434
UniProt	O95096	P42586
RefSeq (mRNA)	NM_002509	NM_001077632 NM_010919
RefSeq (protein)	NP_002500	NP_001071100 NP_035049
Location (UCSC)	Chr 20: 21.51 – 21.51 Mb	Chr 2: 147.18 – 147.19 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.[7]

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.[8]

In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000125820 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027434 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Aug 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes. 47 (8): 1356–1358. doi:10.2337/diabetes.47.8.1356. PMID 9703340.
6. Price M, Lazzaro D, Pohl T, Mattei MG, Rüther U, Olivo JC, Duboule D, Di Lauro R (Feb 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–255. doi:10.1016/0896-6273(92)90291-K. PMID 1346742.
7. "Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)".
8. Tochitani S, Hayashizaki Y (Aug 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications. 372 (4): 691–696. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132.
9. Lovrics A, Gao Y, Juhász B, Bock I, Byrne HM, Dinnyés A, Kovács KA (November 2014). "Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord". PLOS ONE. 9 (11): e111430. doi:10.1371/journal.pone.0111430. PMC 4232242. PMID 25398016.

Further reading

• Hessabi B, Schmidt I, Walther R (Apr 2000). "The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals". Biochemical and Biophysical Research Communications. 270 (3): 695–700. doi:10.1006/bbrc.2000.2491. PMID 10772886.
• Wang CC, Brodnicki T, Copeland NG, Jenkins NA, Harvey RP (Jun 2000). "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals". Mammalian Genome. 11 (6): 466–468. doi:10.1007/s003350010089. PMID 10818213.
• Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD (Oct 2003). "Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex". The Journal of Neuroscience. 23 (29): 9547–9556. doi:10.1523/JNEUROSCI.23-29-09547.2003. PMID 14573534.
• Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL (May 2006). "Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma". Cancer Cell. 9 (5): 405–416. doi:10.1016/j.ccr.2006.04.004. PMID 16697960.
• Pauls S, Zecchin E, Tiso N, Bortolussi M, Argenton F (Apr 2007). "Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts". Developmental Biology. 304 (2): 875–890. doi:10.1016/j.ydbio.2007.01.024. PMID 17335795.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.