RAR-related orphan receptor beta

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.[5]

RORB
Identifiers
Aliases	RORB, NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1, RAR-related orphan receptor beta, RAR related orphan receptor B, EIG15
External IDs	OMIM: 601972 MGI: 1343464 HomoloGene: 38250 GeneCards: RORB
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.13 Start 74,497,335 bp[1] End 74,693,177 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 B Start 18,930,605 bp[2] End 19,111,196 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • transcription factor binding • metal ion binding • steroid hormone receptor activity • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001948 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • melatonin receptor activity Cellular component • nucleoplasm • cell nucleus Biological process • cellular response to retinoic acid • regulation of transcription, DNA-templated • response to stimulus • rhythmic process • retinal cone cell development • negative regulation of osteoblast differentiation • transcription, DNA-templated • positive regulation of transcription, DNA-templated • multicellular organism development • regulation of circadian rhythm • retinal rod cell development • eye photoreceptor cell development • transcription initiation from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • visual perception • steroid hormone mediated signaling pathway • intracellular receptor signaling pathway • amacrine cell differentiation • retina development in camera-type eye • positive regulation of transcription from RNA polymerase II promoter • G-protein coupled receptor signaling pathway • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6096	225998
Ensembl	ENSG00000198963	ENSMUSG00000036192
UniProt	Q92753 Q58EY0	Q8R1B8
RefSeq (mRNA)	NM_006914 NM_001365023	NM_001043354 NM_001289921 NM_146095
RefSeq (protein)	NP_008845 NP_001351952	NP_001036819 NP_001276850 NP_666207
Location (UCSC)	Chr 9: 74.5 – 74.69 Mb	Chr 19: 18.93 – 19.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.[6]

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.[7]

Interactions

RAR-related orphan receptor beta has been shown to interact with NME1.[8]

See also

• RAR-related orphan receptor

References

1. GRCh38: Ensembl release 89: ENSG00000198963 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036192 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. doi:10.1101/gad.8.5.538. PMID 7926749.
6. "Entrez Gene: RORB RAR-related orphan receptor B".
7. Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD (May 2012). "RORβ induces barrel-like neuronal clusters in the developing neocortex". Cereb. Cortex. 22 (5): 996–1006. doi:10.1093/cercor/bhr182. PMC 3328343. PMID 21799210.
8. Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.

Further reading

• Beeson WM, Perry TW, Zurcher TD (1977). "Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle". J. Anim. Sci. 45 (1): 160–5. PMID 885817.
• Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF, Becker-André M (1994). "RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers". Mol. Endocrinol. 8 (6): 757–70. doi:10.1210/me.8.6.757. PMID 7935491.
• Greiner EF, Kirfel J, Greschik H, Dörflinger U, Becker P, Mercep A, Schüle R (1996). "Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10105–10. doi:10.1073/pnas.93.19.10105. PMC 38344. PMID 8816759.
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Park HT, Baek SY, Kim BS, Kim JB, Kim JJ (1996). "Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat". Neurosci. Lett. 217 (1): 17–20. doi:10.1016/S0304-3940(96)13060-3. PMID 8905729.
• André E, Conquet F, Steinmayr M, Stratton SC, Porciatti V, Becker-André M (1998). "Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice". EMBO J. 17 (14): 3867–77. doi:10.1093/emboj/17.14.3867. PMC 1170722. PMID 9670004.
• Greiner EF, Kirfel J, Greschik H, Huang D, Becker P, Kapfhammer JP, Schüle R (2000). "Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7160–5. doi:10.1073/pnas.97.13.7160. PMC 16516. PMID 10860982.
• Gawlas K, Stunnenberg HG (2000). "Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1)". Biochim. Biophys. Acta. 1494 (3): 236–41. doi:10.1016/s0167-4781(00)00237-2. PMID 11121580.
• Gawlas K, Stunnenberg HG (2001). "Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells". Nucleic Acids Res. 29 (16): 3424–32. doi:10.1093/nar/29.16.3424. PMC 55847. PMID 11504880.
• Stehlin C, Wurtz JM, Steinmetz A, Greiner E, Schüle R, Moras D, Renaud JP (2001). "X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation". EMBO J. 20 (21): 5822–31. doi:10.1093/emboj/20.21.5822. PMC 125710. PMID 11689423.
• Sumi Y, Yagita K, Yamaguchi S, Ishida Y, Kuroda Y, Okamura H (2002). "Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus". Neurosci. Lett. 320 (1–2): 13–6. doi:10.1016/S0304-3940(02)00011-3. PMID 11849752.
• Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schüle R (2003). "All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta". Nat. Struct. Biol. 10 (10): 820–5. doi:10.1038/nsb979. PMID 12958591.

External links

• orphan+nuclear+receptor+ROR-beta at the US National Library of Medicine Medical Subject Headings (MeSH)