Homeobox A10

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.[5][6][7]

HOXA10
Identifiers
Aliases	HOXA10, HOX1, HOX1.8, HOX1H, PL, Homeobox A10
External IDs	OMIM: 142957 MGI: 96171 HomoloGene: 7365 GeneCards: HOXA10
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 27,170,592 bp[1] End 27,180,261 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.4 cM Start 52,231,197 bp[2] End 52,240,854 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • histone deacetylase binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • transcription factor complex • cell nucleus Biological process • skeletal system development • proximal/distal pattern formation • male gonad development • regulation of transcription, DNA-templated • transcription, DNA-templated • single fertilization • uterus development • multicellular organism development • embryonic limb morphogenesis • spermatogenesis • regulation of gene expression • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3206	15395
Ensembl	ENSG00000253293	ENSMUSG00000000938
UniProt	P31260	P31310
RefSeq (mRNA)	NM_018951 NM_153715	NM_001122950 NM_008263
RefSeq (protein)	NP_061824	NP_001116422 NP_032289
Location (UCSC)	Chr 7: 27.17 – 27.18 Mb	Chr 6: 52.23 – 52.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.[7] Downregualtion of HOXA10 is observed in the human and baboon decidua after implantation and this downregulation promotes trophoblast invasion by activating STAT3[8]

Interactions

Homeobox A10 has been shown to interact with PTPN6.[9]

See also

• Homeobox

References

1. GRCh38: Ensembl release 89: ENSG00000253293 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000938 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
6. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
7. "Entrez Gene: HOXA10 homeobox A10".
8. Godbole, Geeta; Suman, Pankaj; Malik, Ankita; Galvankar, Mosami; Joshi, Niraj; Fazleabas, Asgi; Gupta, Satish; Modi, Deepak (2017). "Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion". Endocrinology. 158 (8): 2618–2633. doi:10.1210/en.2017-00032. PMC 6283436. PMID 28520923.
9. Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (Sep 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry. 277 (39): 36878–88. doi:10.1074/jbc.M203917200. PMID 12145285.

Further reading

• Eun Kwon H, Taylor HS (Dec 2004). "The role of HOX genes in human implantation". Annals of the New York Academy of Sciences. 1034: 1–18. doi:10.1196/annals.1335.001. PMID 15731295.
• Lowney P, Corral J, Detmer K, LeBeau MM, Deaven L, Lawrence HJ, Largman C (Jun 1991). "A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells". Nucleic Acids Research. 19 (12): 3443–9. doi:10.1093/nar/19.12.3443. PMC 328346. PMID 1676505.
• Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ (Nov 1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proceedings of the National Academy of Sciences of the United States of America. 86 (21): 8536–40. doi:10.1073/pnas.86.21.8536. PMC 298317. PMID 2573064.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK (Dec 1994). "Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12223–7. doi:10.1073/pnas.91.25.12223. PMC 45409. PMID 7527557.
• Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C (Oct 1995). "Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells". Experimental Hematology. 23 (11): 1160–6. PMID 7556525.
• Satokata I, Benson G, Maas R (Mar 1995). "Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice". Nature. 374 (6521): 460–3. doi:10.1038/374460a0. PMID 7700356.
• Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M (Jan 1994). "Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype". Biochemical Pharmacology. 47 (1): 137–43. doi:10.1016/0006-2952(94)90447-2. PMID 7906121.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK (Jan 1997). "Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia". Molecular and Cellular Biology. 17 (1): 495–505. doi:10.1128/mcb.17.1.495. PMC 231774. PMID 8972230.
• Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. doi:10.1128/MCB.17.11.6448. PMC 232497. PMID 9343407.
• Taylor HS, Vanden Heuvel GB, Igarashi P (Dec 1997). "A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes". Biology of Reproduction. 57 (6): 1338–45. doi:10.1095/biolreprod57.6.1338. PMID 9408238.
• Taylor HS, Arici A, Olive D, Igarashi P (Apr 1998). "HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium". The Journal of Clinical Investigation. 101 (7): 1379–84. doi:10.1172/JCI1057. PMC 508715. PMID 9525980.
• Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE (May 1999). "Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells". Leukemia. 13 (5): 687–98. doi:10.1038/sj/leu/2401410. PMID 10374871.
• Eklund EA, Jalava A, Kakar R (Jun 2000). "Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines". The Journal of Biological Chemistry. 275 (26): 20117–26. doi:10.1074/jbc.M907915199. PMID 10766757.
• Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, Humphries RK (Apr 2001). "Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo". Blood. 97 (8): 2286–92. doi:10.1182/blood.V97.8.2286. PMID 11290589.
• Cermik D, Karaca M, Taylor HS (Jul 2001). "HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract". The Journal of Clinical Endocrinology and Metabolism. 86 (7): 3387–92. doi:10.1210/jc.86.7.3387. PMID 11443215.
• Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.

[1][2]

External links

• HOXA10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

1. Godbole, Geeta; Modi, Deepak (2010). "Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox A 10 in endometrial stromal cells". American Journal of Reproductive Immunology. 85 (2): 130–139. doi:10.1016/j.jri.2010.03.003. PMID 20478621.
2. Godbole, Geeta; Puri, CP; Modi, Deepak (2007). "Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli". Reproduction. 134 (3): 513–523. doi:10.1530/REP-07-0234. PMID 17709569.