FOSL1

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.[5][6]

FOSL1
Identifiers
AliasesFOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
External IDsOMIM: 136515 MGI: 107179 HomoloGene: 3967 GeneCards: FOSL1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,892,049 bp[1]
End65,900,573 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8061

14283

Ensembl

ENSG00000175592

ENSMUSG00000024912

UniProt

P15407

P48755

RefSeq (mRNA)

NM_001300844
NM_001300855
NM_001300856
NM_001300857
NM_005438

NM_010235

RefSeq (protein)

NP_001287773
NP_001287784
NP_001287785
NP_001287786
NP_005429

NP_034365

Location (UCSC)Chr 11: 65.89 – 65.9 MbChr 19: 5.45 – 5.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[6]

Interactions

FOSL1 has been shown to interact with USF1 (human gene)[7] and C-jun.[7]

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See also

  • AP-1 (transcription factor)

References

  1. GRCh38: Ensembl release 89: ENSG00000175592 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024912 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–255. PMID 2107490.
  6. "Entrez Gene: FOSL1 FOS-like antigen 1".
  7. Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–2098. doi:10.1038/sj.onc.1201046. PMID 9160889.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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