FOSL1

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.[5][6]

FOSL1
Identifiers
AliasesFOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
External IDsOMIM: 136515 MGI: 107179 HomoloGene: 3967 GeneCards: FOSL1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,892,049 bp[1]
End65,900,573 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8061

14283

Ensembl

ENSG00000175592

ENSMUSG00000024912

UniProt

P15407

P48755

RefSeq (mRNA)

NM_001300844
NM_001300855
NM_001300856
NM_001300857
NM_005438

NM_010235

RefSeq (protein)

NP_001287773
NP_001287784
NP_001287785
NP_001287786
NP_005429

NP_034365

Location (UCSC)Chr 11: 65.89 – 65.9 MbChr 19: 5.45 – 5.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[6]

Interactions

FOSL1 has been shown to interact with USF1 (human gene)[7] and C-jun.[7]

gollark: Java isn't JavaScript.
gollark: Bedrock Edition is *not* free and incompatible with Java Edition servers.
gollark: I thought I had a USB microphone, but it seems to not work somehow.
gollark: Sure, at some point?
gollark: Either that or I'm secretly just a bot.

See also

  • AP-1 (transcription factor)

References

  1. GRCh38: Ensembl release 89: ENSG00000175592 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024912 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–255. PMID 2107490.
  6. "Entrez Gene: FOSL1 FOS-like antigen 1".
  7. Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–2098. doi:10.1038/sj.onc.1201046. PMID 9160889.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.