ELF1

E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene.[5]

ELF1
Identifiers
Aliases	ELF1, E74 like ETS transcription factor 1, EFTUD1, RIA1
External IDs	OMIM: 189973 MGI: 107180 HomoloGene: 7303 GeneCards: ELF1
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.11 Start 40,931,924 bp[1] End 41,061,440 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 79,481,194 bp[2] End 79,582,494 bp[2]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm Biological process • regulation of cytokine production • positive regulation of transcription, DNA-templated • cell differentiation • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • negative regulation of T cell receptor signaling pathway • transcription from RNA polymerase II promoter • regulation of cytokine-mediated signaling pathway • regulation of B cell receptor signaling pathway • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1997	13709
Ensembl	ENSG00000120690	ENSMUSG00000036461
UniProt	P32519	Q60775
RefSeq (mRNA)	NM_001145353 NM_172373 NM_001370329 NM_001370330 NM_001370331 NM_001370332	NM_001286411 NM_001286412 NM_007920
RefSeq (protein)	NP_001138825 NP_758961 NP_001357258 NP_001357259 NP_001357260 NP_001357261	NP_001273340 NP_001273341 NP_031946
Location (UCSC)	Chr 13: 40.93 – 41.06 Mb	Chr 14: 79.48 – 79.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and can act as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000120690 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036461 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: E74-like factor 1 (ets domain transcription factor)".

Further reading

• Xiang P, Lo C, Argiropoulos B, Lai CB, Rouhi A, Imren S, Jiang X, Mager D, Humphries RK (Sep 2010). "Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1". Experimental Hematology. 38 (9): 798–8, 808.e1-2. doi:10.1016/j.exphem.2010.06.006. PMC 3887005. PMID 20600580.
• Juang YT, Solomou EE, Rellahan B, Tsokos GC (Mar 2002). "Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain". Journal of Immunology. 168 (6): 2865–71. doi:10.4049/jimmunol.168.6.2865. PMID 11884456.
• Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD (May 1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Molecular and Cellular Biology. 19 (5): 3635–44. doi:10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
• Nishiyama C, Takahashi K, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T (Dec 2000). "Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1". Bioscience, Biotechnology, and Biochemistry. 64 (12): 2601–7. doi:10.1271/bbb.64.2601. PMID 11210123.
• Thompson CB, Wang CY, Ho IC, Bohjanen PR, Petryniak B, June CH, Miesfeldt S, Zhang L, Nabel GJ, Karpinski B (Mar 1992). "cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1". Molecular and Cellular Biology. 12 (3): 1043–53. doi:10.1128/mcb.12.3.1043. PMC 369536. PMID 1545787.
• Tsokos GC, Nambiar MP, Juang YT (Apr 2003). "Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus". Annals of the New York Academy of Sciences. 987: 240–5. doi:10.1111/j.1749-6632.2003.tb06054.x. PMID 12727645.
• Gunther M, Laithier M, Brison O (Jul 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Molecular and Cellular Biochemistry. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
• Yang W, Tang H, Zhang Y, Tang X, Zhang J, Sun L, et al. (Jan 2013). "Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians". American Journal of Human Genetics. 92 (1): 41–51. doi:10.1016/j.ajhg.2012.11.018. PMC 3542470. PMID 23273568.
• Bassuk AG, Anandappa RT, Leiden JM (May 1997). "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important role in their cooperative activation of the human immunodeficiency virus enhancer in T cells". Journal of Virology. 71 (5): 3563–73. PMC 191503. PMID 9094628.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.