FDU-PB-22

FDU-PB-22
Legal status
Legal status	CA: Schedule II ; DE: Anlage II (Authorized trade only, not prescriptible) ; UK: Under Psychoactive Substances Act ;
Identifiers
	IUPAC name naphthalen-1-yl 1-[(4-fluorophenyl)methyl]-1H-indole-3-carboxylate;
CAS Number	1883284-94-3;
PubChem CID	119025888;
ChemSpider	29763739;
UNII	85E88884ZQ;
Chemical and physical data
Formula	C26H18FNO2
Molar mass	395.433 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC1=C(C=CC=C2)C2=CC=C1)C3=CN(CC4=CC=C(F)C=C4)C5=C3C=CC=C5;
	InChI InChI=1S/C26H18FNO2/c27-20-14-12-18(13-15-20)16-28-17-23(22-9-3-4-10-24(22)28)26(29)30-25-11-5-7-19-6-1-2-8-21(19)25/h1-15,17H,16H2; Key:RCEKSVIFQKKFLS-UHFFFAOYSA-N;

FDU-PB-22 is an derivative of JWH-018 that is presumed to be a potent agonist of the CB₁ receptor and has been sold online as a designer drug.[1][2]

Pharmacology

FDU-PB-22 acts as a full agonist with a binding affinity of 1.19nM at CB₁ and 2.43nM at CB₂ cannabinoid receptors.[3]

Legal status

FDU-PB-22 is a controlled substance in Germany and is banned in Japan and Sweden.[4]

gollark: Entirely different how?

gollark: A while, I assume. They're less common in user-facing systems but there is a large need for them for backups and cold storage and whatever.

gollark: Plus worse write endurance.

gollark: SSDs are still 4x costlier per GB, though.

gollark: Or education in general, really, but particularly that case.

References

"FDU-PB-22". Southern Association of Forensic Scientists. Archived from the original on 27 May 2015. Retrieved 23 July 2015.
Uchiyama, Nahoko; Shimokawa, Yoshihiko; Kikura-Hanajiri, Ruri; Demizu, Yosuke; Goda, Yukihiro; Hakamatsuka, Takashi (1 July 2015). "A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products". Forensic Toxicology. 33 (2): 244–259. doi:10.1007/s11419-015-0268-7. ISSN 1860-8965. PMC 4525202. PMID 26257833.
Hess, Cornelius; Schoeder, ClaraT.; Pillaiyar, Thanigaimalai; Madea, Burkhard; Müller, ChristaE. (1 July 2016). "Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice". Forensic Toxicology. 34 (2): 329–343. doi:10.1007/s11419-016-0320-2. ISSN 1860-8965. PMC 4929166. PMID 27429655.
"Cannabinoider föreslås bli klassificerade som hälsofarlig vara". Folkhälsomyndigheten. 28 May 2014. Retrieved 23 July 2015.

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[1] "FDU-PB-22". Southern Association of Forensic Scientists. Archived from the original on 27 May 2015. Retrieved 23 July 2015.

[Uchiyama_2015-2] Uchiyama, Nahoko; Shimokawa, Yoshihiko; Kikura-Hanajiri, Ruri; Demizu, Yosuke; Goda, Yukihiro; Hakamatsuka, Takashi (1 July 2015). "A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products". Forensic Toxicology. 33 (2): 244–259. doi:10.1007/s11419-015-0268-7. ISSN 1860-8965. PMC 4525202. PMID 26257833.

[3] Hess, Cornelius; Schoeder, ClaraT.; Pillaiyar, Thanigaimalai; Madea, Burkhard; Müller, ChristaE. (1 July 2016). "Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice". Forensic Toxicology. 34 (2): 329–343. doi:10.1007/s11419-016-0320-2. ISSN 1860-8965. PMC 4929166. PMID 27429655.

[4] "Cannabinoider föreslås bli klassificerade som hälsofarlig vara". Folkhälsomyndigheten. 28 May 2014. Retrieved 23 July 2015.

FDU-PB-22

Pharmacology

Legal status

See also

References