Analgesic adjuvant

An analgesic adjuvant is a medication that is typically used for indications other than pain control but provides control of pain in some painful diseases. Antiemetics and medication to relieve constipation are two examples of non-adjuvant medication indications because these are used to treat side effects and adverse effects.[1] Examples include:

amitriptyline[2]
antihistamines (e.g. hydroxyzine, promethazine)
carisoprodol
cyclobenzaprine
dextromethorphan[3]
duloxetine
gabapentin
hyoscine (scopolamine)
pregabalin
stimulants (e.g. caffeine, cocaine, dextroamphetamine, ephedrine)
venlafaxine

The exact mechanism of carbamazepine, gabapentin, and pregabalin is similarly unclear, but these anticonvulsants are used to treat neuropathic pain with differing degrees of success.[4]

References

"WHO Guidelines on the Pharmacological Treatment of Persisting Pain in Children with Medical Illnesses" (PDF). World Health Organization. 2012. Retrieved 21 August 2017.
Bryson, HM; Wilde, MI (1 June 1996). "Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states". Drugs & Aging. 8 (6): 459–476. doi:10.2165/00002512-199608060-00008. PMID 8736630.
Elliott, KJ; Brodsky, M; Hynansky, A; Foley, KM; Inturrisi, CE. Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance. NEUROLOGY, 2005.
Eardley, I; Whelan, P; Kirby, R; Schaeffer, A. "Drugs Used In The Treatment Of Interstitial Cystitis". Drug Treatment in Urology. John Wiley & Sons, 2008. p. 65.

External links

WHO Guidelines on the Pharmacological Treatment of Persisting Pain in Children with Medical Illnesses, (2012), World Health Organization

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[who-1] "WHO Guidelines on the Pharmacological Treatment of Persisting Pain in Children with Medical Illnesses" (PDF). World Health Organization. 2012. Retrieved 21 August 2017.

[2] Bryson, HM; Wilde, MI (1 June 1996). "Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states". Drugs & Aging. 8 (6): 459–476. doi:10.2165/00002512-199608060-00008. PMID 8736630.

[3] Elliott, KJ; Brodsky, M; Hynansky, A; Foley, KM; Inturrisi, CE. Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance. NEUROLOGY, 2005.

[4] Eardley, I; Whelan, P; Kirby, R; Schaeffer, A. "Drugs Used In The Treatment Of Interstitial Cystitis". Drug Treatment in Urology. John Wiley & Sons, 2008. p. 65.