QUCHIC

QUCHIC (BB-22, SGT-32 or 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and was first detected being sold in synthetic cannabis products in Japan in early 2013,[1] and subsequently also in New Zealand.[2] The structure of QUCHIC appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. QUCHIC, along with QUPIC, represents a structurally unique synthetic cannabinoid chemotype since it contains an ester linker at the indole 3-position rather than the precedented ketone of JWH-018 and its analogues, or the amide of SDB-001 and its analogues.

QUCHIC
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H24N2O2
Molar mass384.479 g·mol−1
3D model (JSmol)

Pharmacology

BB-22 acts as a full agonist with a binding affinity of 0.217nM at CB1 and 0.338nM at CB2 cannabinoid receptors.[3]

gollark: No generics, reliance on compiler magic, utterly horrific versioning, ugly syntax, multiple returns instead of ADTs/tuples.
gollark: What if you implement Go in Go?
gollark: \@everyone
gollark: Go(lang) = bad.
gollark: ``` [...] MIPS is short for Millions of Instructions Per Second. It is a measure for the computation speed of a processor. Like most such measures, it is more often abused than used properly (it is very difficult to justly compare MIPS for different kinds of computers). BogoMips are Linus's own invention. The linux kernel version 0.99.11 (dated 11 July 1993) needed a timing loop (the time is too short and/or needs to be too exact for a non-busy-loop method of waiting), which must be calibrated to the processor speed of the machine. Hence, the kernel measures at boot time how fast a certain kind of busy loop runs on a computer. "Bogo" comes from "bogus", i.e, something which is a fake. Hence, the BogoMips value gives some indication of the processor speed, but it is way too unscientific to be called anything but BogoMips. The reasons (there are two) it is printed during boot-up is that a) it is slightly useful for debugging and for checking that the computer[’]s caches and turbo button work, and b) Linus loves to chuckle when he sees confused people on the news. [...]```I was wondering what BogoMIPS was, and wikipedia had this.

See also

References
  1. Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y (2013). "Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products". Forensic Toxicology. 31 (2): 223–240. doi:10.1007/s11419-013-0182-9.
  2. Dunne bans further two substances found in K2. Press Release: New Zealand Government. Tuesday, 30 April 2013
  3. Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE (1 July 2016). "Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice". Forensic Toxicology. 34 (2): 329–343. doi:10.1007/s11419-016-0320-2. PMC 4929166. PMID 27429655.
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