Dihydrodeoxycorticosterone
5α-Dihydrodeoxycorticosterone (abbreviated as DHDOC), also known as 21-hydroxy-5α-pregnan-20-one, is an endogenous progestogen and neurosteroid.[1] It is synthesized from the adrenal hormone deoxycorticosterone (DOC) by the enzyme 5α-reductase type I.[1] DHDOC is an agonist of the progesterone receptor, as well as a positive allosteric modulator of the GABAA receptor, and is known to have anticonvulsant effects.[1][2]
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| Names | |
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| IUPAC name
(5α)-21-Hydroxypregnane-3,20-dione | |
| Other names
5α-Dihydro-11-deoxycorticosterone | |
| Identifiers | |
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| Properties | |
| C21H32O3 | |
| Molar mass | 332.484 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Chemistry
gollark: I mean, I've *visited* Russia, which is... somewhat authoritarian? but that's basically the extent of it.
gollark: Indeed. I also don't want to.
gollark: Which is to say, you probably can do it but it would also be very bad.
gollark: No, not really. If you give some entity control of speech it will be abused horribly.
gollark: I see you have found a different meme which doesn't say "gender".
See also
- Tetrahydrodeoxycorticosterone (THDOC)
- 5α-Dihydroprogesterone (DHP)
- Hydroxydione
References
- Reddy DS, Rogawski MA (May 2002). "Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility". J. Neurosci. 22 (9): 3795–805. doi:10.1523/JNEUROSCI.22-09-03795.2002. PMID 11978855.
- Edwards HE, Vimal S, Burnham WM (December 2005). "The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses". Epilepsia. 46 (12): 1888–97. doi:10.1111/j.1528-1167.2005.00295.x. PMID 16393154.
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