Flugestone acetate

Flugestone acetate (FGA), sold under the brand name Cronolone among others, is a progestin medication which is used in veterinary medicine.[1][2][3][4][5][6]

Flugestone acetate
Clinical data
Trade namesCronolone, others
Other namesFlurogestone acetate; Fluorogestone acetate; FGA; NSC-65411; SC-9880; 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone
Routes of
administration		Intravaginal
Drug classProgestogen; Progestin; Progestogen ester
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.017.979
Chemical and physical data
FormulaC23H31FO5
Molar mass406.494 g·mol−1
3D model (JSmol)

Uses

Veterinary

FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats.[2][4][5][6]

Chemistry
See also: List of progestogens, Progestogen ester, and List of progestogen esters

FGA, also known as 17α-acetoxy-9α-fluoro-11β-hydroxyprogesterone or as 17α-acetoxy-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone.[1][3] It is the C17α acetate ester of flugestone.[1][3][2]

History

FGA was developed and marketed by G.D. Searle & Company in the 1960s.[7][8]

Society and culture

Generic names

Flugestone acetate is the generic name of the drug and its INN and BANM, while flurogestone acetate is its USAN.[1][3][2][9] Flugestone is the BAN and DCIT of the unesterified free alcohol form.[1][3][2][9] FGA is also known by its developmental code names NSC-65411 and SC-9880.[1][3][2][9]

Brand names

FGA is or has been marketed under the brand names Chronogest, Chrono-Gest, Crono-Gest, Cronolone, Gyncro-Mate, Ova-Gest, Ovakron, Synchro-Mate, Syncro Part, and Syncropart.[1][3][2][9]

Availability

FGA is marketed for veterinary use in Australia, France, Ireland, Israel, Italy, the Netherlands, South Africa, and the United Kingdom.[3][9]

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References
  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 559. ISBN 978-1-4757-2085-3.
  2. Dr. Ian Morton; I.K. Morton; Judith M. Hall (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 122–. ISBN 978-0-7514-0499-9.
  3. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 451–. ISBN 978-3-88763-075-1.
  4. Office of the Federal Register (U S ); U. s. Government Printing Office (29 May 2012). Code of Federal Regulations Title 21: Food and Drug Administration: Parts 500-599, Revised April 1, 2012. Government Printing Office. pp. 359–. ISBN 978-0-16-090718-0.
  5. Robert S. Youngquist; Walter R. Threlfall (23 November 2006). Current Therapy in Large Animal Theriogenology. Elsevier Health Sciences. pp. 2640–. ISBN 1-4377-1340-8.
  6. Virginia P. Studdert; Clive C. Gay; Douglas C. Blood (9 December 2011). Saunders Comprehensive Veterinary Dictionary. Elsevier Health Sciences. pp. 2673–. ISBN 0-7020-4744-9.
  7. Animal Husbandry Research: Reports on Agricultural Industry. 1967. p. 60.
  8. Dairy Science Handbook. Agriservices Foundation. 1971. p. 10.
  9. https://www.drugs.com/international/flugestone.html


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