Cyclopyrrolones
Cyclopyrrolones are a family of hypnotic and anxiolytic nonbenzodiazepine drugs with similar pharmacological profiles to the benzodiazepine derivatives.
![](../I/m/Cyclopyrrolone.svg.png)
Skeletal formula of the parent compound, cyclopyrrolone
Although cyclopyrrolones are chemically unrelated to benzodiazepines, they function via the benzodiazepine receptor of neurotransmitter GABA. The best-known cyclopyrrolone derivatives are zopiclone (Imovane) and its active single-enantiomer component, eszopiclone (Lunesta), which are used to treat insomnia, and have a known potential for abuse. Other cyclopyrrolones include:
- Eszopiclone—hypnotic (Lunesta)
- Pagoclone—anxiolytic
- Pazinaclone—anxiolytic
- Suproclone—anxiolytic
- Suriclone—anxiolytic
- Zopiclone—hypnotic (Imovane)
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