Lofendazam

Lofendazam[1] is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam. [2][3]

Lofendazam

Clinical data
ATC code	none
Identifiers
IUPAC name 8-chloro-1-phenyl-1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-one
CAS Number	29176-29-2^Y
PubChem CID	71709
ChemSpider	64759^Y
UNII	V7O53S50SN
CompTox Dashboard (EPA)	DTXSID30183436
ECHA InfoCard	100.044.975
Chemical and physical data
Formula	C15H13ClN2O
Molar mass	272.73 g·mol^−1
3D model (JSmol)	Interactive image
SMILES Clc3ccc1c(N(C(=O)CCN1)c2ccccc2)c3
InChI InChI=1S/C15H13ClN2O/c16-11-6-7-13-14(10-11)18(15(19)8-9-17-13)12-4-2-1-3-5-12/h1-7,10,17H,8-9H2^Y Key:IUJQOUHDFKALCY-UHFFFAOYSA-N^Y
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Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.[4]

See also

• Benzodiazepine
• Arfendazam
• Clobazam

References

1. DE Patent 1929656
2. Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W. Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. Liebigs Annalen der Chemie, 1995. (10):1861-1869.
3. Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG. Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-ones. Organic Magnetic Resonance, 1981. 15(4):394-398
4. J. Adrien, F. Albani, A. Baruzzi, M. Berger, E.O. Bixler, A.A. Borbeley, D.G. Dikeos, R. Drucker-Colin, R. Fritsch Montero, Y. Hishikawa, S. Inoue, A. Kales, E. Lugaresi, H. Merchant-Nancy, J.M. Monti. The Pharmacology of Sleep. Springer. ISBN 978-3-540-58961-7