GBLD-345

GBLD-345 is an anxiolytic drug used in scientific research, which acts as a non-selective, full-efficacy positive allosteric modulator of the GABA_A receptor. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1]

GBLD-345

Identifiers
IUPAC name 2-(4-aminophenyl)-3-methoxy-N-[(3-methoxyphenyl)methyl] imidazo[2,1-f]pyridazin-6-amine
CAS Number	122479-08-7
PubChem CID	4602899
ChemSpider	3794457
ChEMBL	ChEMBL1339029
Chemical and physical data
Formula	C21H21N5O2
Molar mass	375.432 g·mol^−1
3D model (JSmol)	Interactive image
SMILES COC1=CC=CC(CNC(C=C2)=NN3C2=NC(C4=CC=C(N)C=C4)=C3OC)=C1
InChI InChI=1S/C21H21N5O2/c1-27-17-5-3-4-14(12-17)13-23-18-10-11-19-24-20(21(28-2)26(19)25-18)15-6-8-16(22)9-7-15/h3-12H,13,22H2,1-2H3,(H,23,25) Key:HQRHGSRWOHGIRI-UHFFFAOYSA-N
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References

1. Davies LP, Barlin GB, Ireland SJ, Ngu MM (October 1992). "Substituted imidazo[1,2-b]pyridazines. New compounds with activity at central and peripheral benzodiazepine receptors". Biochemical Pharmacology. 44 (8): 1555–61. doi:10.1016/0006-2952(92)90472-U. PMID 1358075.