Choline transporter-like protein 1

Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene.[5][6][7]

SLC44A1
Identifiers
Aliases	SLC44A1, CD92, CDW92, CHTL1, CTL1, solute carrier family 44 member 1, CONATOC
External IDs	OMIM: 606105 MGI: 2140592 HomoloGene: 11137 GeneCards: SLC44A1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.1-q31.2 Start 105,244,622 bp[1] End 105,439,171 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B2 Start 53,440,413 bp[2] End 53,622,478 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • choline transmembrane transporter activity Cellular component • extracellular exosome • nucleoplasm • mitochondrion • cell membrane • integral component of membrane • mitochondrial outer membrane • membrane Biological process • phosphatidylcholine biosynthetic process • transmembrane transport • choline transport • choline catabolic process • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23446	100434
Ensembl	ENSG00000070214	ENSMUSG00000028412
UniProt	Q8WWI5	Q6X893
RefSeq (mRNA)	NM_001286730 NM_022109 NM_080546 NM_001330731	NM_001159633 NM_133891 NM_001374697
RefSeq (protein)	NP_001273659 NP_001317660 NP_536856	NP_001153105 NP_598652 NP_001361626
Location (UCSC)	Chr 9: 105.24 – 105.44 Mb	Chr 4: 53.44 – 53.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Cluster of differentiation
• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000070214 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028412 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wille S, Szekeres A, Majdic O, Prager E, Staffler G, Stöckl J, Kunthalert D, Prieschl EE, Baumruker T, Burtscher H, Zlabinger GJ, Knapp W, Stockinger H (November 2001). "Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells". Journal of Immunology. 167 (10): 5795–5804. doi:10.4049/jimmunol.167.10.5795. PMID 11698453.
6. O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (February 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 97 (4): 1835–40. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.
7. "Entrez Gene: SLC44A1 solute carrier family 44, member 1".

Further reading

• Yuan Z, Tie A, Tarnopolsky M, Bakovic M (June 2006). "Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1" (PDF). Physiological Genomics. 26 (1): 76–90. doi:10.1152/physiolgenomics.00107.2005. PMID 16609143.
• Fullerton MD, Wagner L, Yuan Z, Bakovic M (April 2006). "Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages" (PDF). American Journal of Physiology. Cell Physiology. 290 (4): C1230–C1238. doi:10.1152/ajpcell.00255.2005. PMID 16319125.
• Li D, Wang F, Lai M, Chen Y, Zhang JF (February 2005). "A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C". The Journal of Neuroscience. 25 (8): 1914–23. doi:10.1523/JNEUROSCI.4790-04.2005. PMID 15728831.
• Traiffort E, Ruat M, O'Regan S, Meunier FM (March 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". Journal of Neurochemistry. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662.
• Lecomte MJ, De Gois S, Guerci A, Ravassard P, Faucon Biguet N, Mallet J, Berrard S (February 2005). "Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia". Molecular and Cellular Neurosciences. 28 (2): 303–13. doi:10.1016/j.mcn.2004.09.014. PMID 15691711.
• Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P (December 2003). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proceedings of the National Academy of Sciences of the United States of America. 100 (26): 16006–11. doi:10.1073/pnas.2136600100. PMC 307683. PMID 14663150.
• Takekawa M, Maeda T, Saito H (August 1998). "Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways". The EMBO Journal. 17 (16): 4744–52. doi:10.1093/emboj/17.16.4744. PMC 1170803. PMID 9707433.

External links

• SLC44A1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)