Zinc transporter ZIP4

Zinc transporter ZIP4 is a transmembrane protein which in humans is encoded by the SLC39A4 gene. It is associated with acrodermatitis enteropathica.[5]

SLC39A4
Identifiers
Aliases	SLC39A4, AEZ, AWMS2, ZIP4, solute carrier family 39 member 4
External IDs	OMIM: 607059 MGI: 1919277 HomoloGene: 15638 GeneCards: SLC39A4
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,409,742 bp[1] End 144,416,895 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,612,383 bp[2] End 76,617,384 bp[2]
Gene ontology Molecular function • metal ion transmembrane transporter activity • zinc ion transmembrane transporter activity Cellular component • integral component of membrane • endosome • recycling endosome membrane • cell membrane • membrane • integral component of plasma membrane • cytoplasmic vesicle • apical plasma membrane Biological process • metal ion transport • zinc II ion transport • ion transport • zinc II ion transmembrane import • transmembrane transport • signal transduction • cellular zinc ion homeostasis • cellular response to zinc ion starvation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55630	72027
Ensembl	ENSG00000147804 ENSG00000285243	ENSMUSG00000063354
UniProt	Q6P5W5	Q78IQ7
RefSeq (mRNA)	NM_001280557 NM_017767 NM_130849 NM_001374839	NM_028064
RefSeq (protein)	NP_001267486 NP_060237 NP_570901 NP_001361768	NP_082340
Location (UCSC)	Chr 8: 144.41 – 144.42 Mb	Chr 15: 76.61 – 76.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. ENSG00000285243 GRCh38: Ensembl release 89: ENSG00000147804, ENSG00000285243 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063354 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kambe T, Andrews GK (January 2009). "Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations". Mol. Cell. Biol. 29 (1): 129–39. doi:10.1128/MCB.00963-08. PMC 2612479. PMID 18936158.

External links

• OMIM entry on ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE; AEZ

• Beigi, Pooya Khan Mohammd; Maverakis, Emanual (2015). Acrodermatitis Enteropathica: A Clinician's Guide. Springer. ISBN 9783319178196. Retrieved 18 February 2017.