SLC25A29

Solute carrier family 25, member 29 is a protein that in humans is encoded by the SLC25A29 gene.[1] The gene is also known as CACL and C14orf69.[1] SLC25A29 belongs to a protein family of solute carriers called the mitochondrial carriers.[1]

Model organisms

Model organisms have been used in the study of SLC25A29 function. A conditional knockout mouse line, called Slc25a29tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty four tests were carried out on mutant mice, but no significant abnormalities were observed.[4]

gollark: Weird.
gollark: Nowadays, if someone came up with the idea of sending privileged system messages down something the user could easily read/write to, they would probably not be taken seriously, but it seems like they just... didn't think of the security implications? Or thought doing it differently would be too costly maybe.
gollark: It seems really bizarre that people came up with this whole in-band signalling system and thought it was a good idea.
gollark: To get free long distance calls.
gollark: The main thing I heard about with that was spoofing something involved in long distance calling.

References
  1. "Solute carrier family 25, member 29". Retrieved 2011-12-05.
  2. "Salmonella infection data for Slc25a29". Wellcome Trust Sanger Institute.
  3. "Citrobacter infection data for Slc25a29". Wellcome Trust Sanger Institute.
  4. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  5. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. "International Knockout Mouse Consortium".
  7. "Mouse Genome Informatics".
  8. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. Collins FS; Rossant J; Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. van der Weyden L; White JK; Adams DJ; Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.