RHBG

Rh family, B glycoprotein, also known as RHBG, is an ammonia transporter protein which in humans is encoded by the RHBG gene.[5][6]

RHBG
Identifiers
Aliases	RHBG, SLC42A2, Rh family B glycoprotein (gene/pseudogene), Rh family B glycoprotein
External IDs	OMIM: 607079 MGI: 1927379 HomoloGene: 9469 GeneCards: RHBG
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,369,211 bp[1] End 156,385,219 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.78 cM Start 88,242,874 bp[2] End 88,254,709 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ankyrin binding • GO:0051739 ammonium transmembrane transporter activity Cellular component • spectrin-associated cytoskeleton • integral component of membrane • anchored component of plasma membrane • integral component of plasma membrane • cytoplasmic vesicle membrane • membrane • cytoplasmic vesicle • cell membrane • basolateral plasma membrane Biological process • ammonium transmembrane transport • organic cation transport • transepithelial ammonium transport • ammonium transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57127	58176
Ensembl	ENSG00000132677	ENSMUSG00000104445
UniProt	Q9H310	Q8BUX5
RefSeq (mRNA)	NM_001256395 NM_001256396 NM_020407	NM_021375
RefSeq (protein)	NP_001243324 NP_001243325 NP_065140	NP_067350
Location (UCSC)	Chr 1: 156.37 – 156.39 Mb	Chr 3: 88.24 – 88.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

RHBG and RHCG are non-erythroid members of the Rhesus (Rh) protein family that are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. Rh family proteins are all predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000132677 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000104445 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RHBG Rh family, B glycoprotein".
6. Liu Z, Peng J, Mo R, Hui C, Huang CH (January 2001). "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals". J. Biol. Chem. 276 (2): 1424–33. doi:10.1074/jbc.M007528200. PMID 11024028.

Further reading

• Huang CH, Liu PZ (2001). "New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues". Blood Cells Mol. Dis. 27 (1): 90–101. doi:10.1006/bcmd.2000.0355. PMID 11358367.
• Liu Z, Chen Y, Mo R, et al. (2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.
• Liu Z, Peng J, Mo R, et al. (2001). "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals". J. Biol. Chem. 276 (2): 1424–33. doi:10.1074/jbc.M007528200. PMID 11024028.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ludewig U (2005). "Electroneutral ammonium transport by basolateral rhesus B glycoprotein". J. Physiol. 559 (Pt 3): 751–9. doi:10.1113/jphysiol.2004.067728. PMC 1665183. PMID 15284342.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lopez C, Métral S, Eladari D, et al. (2005). "The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells". J. Biol. Chem. 280 (9): 8221–8. doi:10.1074/jbc.M413351200. PMID 15611082.
• Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, et al. (2006). "Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells". Biochem. J. 391 (Pt 1): 33–40. doi:10.1042/BJ20050657. PMC 1237136. PMID 15929723.
• Huang CH, Peng J (2005). "Evolutionary conservation and diversification of Rh family genes and proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15512–7. doi:10.1073/pnas.0507886102. PMC 1266151. PMID 16227429.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.