Solute carrier organic anion transporter family member 2A1

Solute carrier organic anion transporter family member 2A1, also known as the prostaglandin transporter (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.[5]

SLCO2A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MRR
Identifiers
Aliases	SLCO2A1, MATR1, OATP2A1, PGT, PHOAR2, SLC21A2, solute carrier organic anion transporter family member 2A1
External IDs	OMIM: 601460 MGI: 1346021 HomoloGene: 38077 GeneCards: SLCO2A1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.1-q22.2 Start 133,932,701 bp[1] End 134,052,184 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 54.72 cM Start 102,988,712 bp[2] End 103,096,002 bp[2]
Gene ontology Molecular function • transporter activity • lipid transporter activity • prostaglandin transmembrane transporter activity • sodium-independent organic anion transmembrane transporter activity Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane Biological process • lipid transport • prostaglandin transport • sodium-independent organic anion transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6578	24059
Ensembl	ENSG00000174640	ENSMUSG00000032548
UniProt	Q92959	Q9EPT5
RefSeq (mRNA)	NM_005630	NM_033314
RefSeq (protein)	NP_005621	NP_201571
Location (UCSC)	Chr 3: 133.93 – 134.05 Mb	Chr 9: 102.99 – 103.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.[5]

Clinical relevance

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000174640 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032548 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". Retrieved 2011-12-30.
6. Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y (January 2012). "Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy". American Journal of Human Genetics. 90 (1): 125–32. doi:10.1016/j.ajhg.2011.11.019. PMC 3257902. PMID 22197487.

Further reading

• Hagenbuch B, Meier PJ (February 2004). "Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties" (PDF). Pflügers Archiv. 447 (5): 653–65. doi:10.1007/s00424-003-1168-y. PMID 14579113.
• Huang CS, Huang MJ, Lin MS, Yang SS, Teng HC, Tang KS (January 2005). "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenetics and Genomics. 15 (1): 43–50. doi:10.1097/01213011-200501000-00007. PMID 15864125.
• Kang J, Chapdelaine P, Laberge PY, Fortier MA (March 2006). "Functional characterization of prostaglandin transporter and terminal prostaglandin synthases during decidualization of human endometrial stromal cells". Human Reproduction. 21 (3): 592–9. doi:10.1093/humrep/dei400. PMID 16339169.
• Choi K, Zhuang H, Crain B, Doré S (March 2008). "Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls". Journal of Neuroimmunology. 195 (1–2): 81–7. doi:10.1016/j.jneuroim.2008.01.014. PMC 2365511. PMID 18353443.
• Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN (July 2008). "Regulation of prostaglandin transporters in colorectal neoplasia". Cancer Prevention Research. 1 (2): 93–9. doi:10.1158/1940-6207.CAPR-07-0009. PMID 19138942.
• Chi Y, Schuster VL (April 2010). "The prostaglandin transporter PGT transports PGH(2)". Biochemical and Biophysical Research Communications. 395 (2): 168–72. doi:10.1016/j.bbrc.2010.03.108. PMC 4410840. PMID 20346915.
• Breuiller-Fouché M, Leroy MJ, Dubois O, Reinaud P, Chissey A, Qi H, Germain G, Fortier MA, Charpigny G (July 2010). "Differential expression of the enzymatic system controlling synthesis, metabolism, and transport of PGF2 alpha in human fetal membranes". Biology of Reproduction. 83 (1): 155–62. doi:10.1095/biolreprod.109.080390. PMID 20357271.
• Lu R, Kanai N, Bao Y, Schuster VL (September 1996). "Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)". The Journal of Clinical Investigation. 98 (5): 1142–9. doi:10.1172/JCI118897. PMC 507536. PMID 8787677.
• Lu R, Schuster VL (May 1998). "Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization". Biochemical and Biophysical Research Communications. 246 (3): 805–12. doi:10.1006/bbrc.1998.8715. PMID 9618293.
• Topper JN, Cai J, Stavrakis G, Anderson KR, Woolf EA, Sampson BA, Schoen FJ, Falb D, Gimbrone MA (December 1998). "Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo". Circulation. 98 (22): 2396–403. doi:10.1161/01.CIR.98.22.2396. PMID 9832484.

External links

• Overview of all the structural information available in the PDB for UniProt: Q92959 (Solute carrier organic anion transporter family member 2A1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.