Choline transporter-like protein 2

Choline transporter-like protein 2 is a protein that in humans is encoded by the SLC44A2 gene.[5][6][7]

SLC44A2
Identifiers
Aliases	SLC44A2, CTL2, PP1292, solute carrier family 44 member 2
External IDs	OMIM: 606106 MGI: 1915932 HomoloGene: 10711 GeneCards: SLC44A2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,602,457 bp[1] End 10,644,557 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 21,320,698 bp[2] End 21,355,028 bp[2]
Gene ontology Molecular function • choline transmembrane transporter activity • signal transducer activity Cellular component • integral component of membrane • lysosomal membrane • cell membrane • extracellular exosome • membrane • specific granule membrane Biological process • positive regulation of I-kappaB kinase/NF-kappaB signaling • phosphatidylcholine biosynthetic process • choline transport • transmembrane transport • signal transduction • neutrophil degranulation • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57153	68682
Ensembl	ENSG00000129353	ENSMUSG00000057193
UniProt	Q8IWA5	Q8BY89
RefSeq (mRNA)	NM_001145056 NM_020428 NM_001363611	NM_001199186 NM_152808 NM_001359227
RefSeq (protein)	NP_001138528 NP_065161 NP_001350540	NP_001186115 NP_690021 NP_001346156
Location (UCSC)	Chr 19: 10.6 – 10.64 Mb	Chr 9: 21.32 – 21.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000129353 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057193 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proc Natl Acad Sci U S A. 97 (4): 1835–40. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.
6. Traiffort E, Ruat M, O'Regan S, Meunier FM (Feb 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". J Neurochem. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662.
7. "Entrez Gene: SLC44A2 solute carrier family 44, member 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Nair TS, Kozma KE, Hoefling NL, et al. (2004). "Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss". J. Neurosci. 24 (7): 1772–9. doi:10.1523/JNEUROSCI.5063-03.2004. PMID 14973250.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.