SLC22A14

Solute carrier family 22 member 14 is a protein that in humans is encoded by the SLC22A14 gene.[5]

SLC22A14
Identifiers
Aliases	SLC22A14, OCTL2, OCTL4, ORCTL4, solute carrier family 22 member 14
External IDs	OMIM: 604048 MGI: 2685974 HomoloGene: 3530 GeneCards: SLC22A14
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 38,282,294 bp[1] End 38,318,575 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 119,169,455 bp[2] End 119,365,553 bp[2]
Gene ontology Molecular function • organic cation transmembrane transporter activity • GO:0022891 transmembrane transporter activity • inorganic anion exchanger activity • sodium-independent organic anion transmembrane transporter activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane Biological process • organic cation transport • transmembrane transport • inorganic anion transport • sodium-independent organic anion transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9389	382113
Ensembl	ENSG00000144671	ENSMUSG00000070280
UniProt	Q9Y267	n/a
RefSeq (mRNA)	NM_004803 NM_001320033	NM_001037749
RefSeq (protein)	NP_001306962 NP_004794	n/a
Location (UCSC)	Chr 3: 38.28 – 38.32 Mb	Chr 9: 119.17 – 119.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

References

1. GRCh38: Ensembl release 89: ENSG00000144671 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070280 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 22 member 14". Retrieved 2020-01-19.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.