UDP-galactose translocator

UDP-galactose translocator is a protein that in humans is encoded by the SLC35A2 gene.[3][4]

SLC35A2
Identifiers
Aliases	SLC35A2, CDG2M, CDGX, UDP-Gal-Tr, UGALT, UGAT, UGT, UGT1, UGT2, UGTL, solute carrier family 35 member A2
External IDs	OMIM: 314375 HomoloGene: 136614 GeneCards: SLC35A2
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.23 Start 48,903,180 bp[1] End 48,911,958 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • UDP-galactose transmembrane transporter activity • pyrimidine nucleotide-sugar transmembrane transporter activity Cellular component • integral component of membrane • Golgi membrane • Golgi apparatus • endoplasmic reticulum • cell nucleus • membrane • integral component of Golgi membrane Biological process • galactose metabolic process • carbohydrate transport • UDP-galactose transmembrane transport • pyrimidine nucleotide-sugar transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7355	n/a
Ensembl	ENSG00000102100	n/a
UniProt	P78381	n/a
RefSeq (mRNA)	NM_005660 NM_001032289 NM_001042498 NM_001282647 NM_001282648 NM_001282649 NM_001282650 NM_001282651	n/a
RefSeq (protein)	NP_001027460 NP_001035963 NP_001269576 NP_001269577 NP_001269578 NP_001269579 NP_001269580 NP_005651	n/a
Location (UCSC)	Chr X: 48.9 – 48.91 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000102100 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hara T, Yamauchi M, Takahashi E, Hoshino M, Aoki K, Ayusawa D, Kawakita M (Apr 1994). "The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus". Somat Cell Mol Genet. 19 (6): 571–5. doi:10.1007/BF01233383. PMID 8128316.
4. "Entrez Gene: SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Miura N, Ishida N, Hoshino M, et al. (1997). "Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator". J. Biochem. 120 (2): 236–41. doi:10.1093/oxfordjournals.jbchem.a021404. PMID 8889805.
• Ishida N, Miura N, Yoshioka S, Kawakita M (1997). "Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family". J. Biochem. 120 (6): 1074–8. doi:10.1093/oxfordjournals.jbchem.a021523. PMID 9010752.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yoshioka S, Sun-Wada GH, Ishida N, Kawakita M (1998). "Expression of the human UDP-galactose transporter in the Golgi membranes of murine Had-1 cells that lack the endogenous transporter". J. Biochem. 122 (4): 691–5. doi:10.1093/oxfordjournals.jbchem.a021810. PMID 9399569.
• Aoki K, Ishida N, Kawakita M (2001). "Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid". J. Biol. Chem. 276 (24): 21555–61. doi:10.1074/jbc.M101462200. PMID 11279205.
• Kumamoto K, Goto Y, Sekikawa K, et al. (2001). "Increased expression of UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis A/X determinants". Cancer Res. 61 (11): 4620–7. PMID 11389099.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sprong H, Degroote S, Nilsson T, et al. (2004). "Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum". Mol. Biol. Cell. 14 (8): 3482–93. doi:10.1091/mbc.E03-03-0130. PMC 181583. PMID 12925779.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.